Steroid contraception -⁠ the influence on bone metabolismReview articles

Fait Tomáš

Clin Osteol 2024; 29(4): 122-127 | DOI: 10.36290/clo.2024.014

The combined hormonal contraception have positive influence on bone mineral density due to its estrogen component. This effect could have clinical application in group of women with menstrual cycle´s disorders and in perimenopausal women. Extremely low doses of ethinylestradiol could forestall the achievement of bone mineral density peak. Depot medroxyprogesterone acetate is not suitable contraception for women with risk of osteoporosis.

Několik slov úvodemEditorial

prof. MUDr. Vladimír Palička, CSc., dr.h.c.

Clin Osteol 2024; 29(4): 119-120

27. kongres slovenských a českých osteológovAbstracts

Clin Osteol 2024; 29(3): 87-113

Výber z najnovších vedeckých informácií v osteológiiLiterature

Šteňová Ke Em

Clin Osteol 2024; 29(3): 84-86

The EGFR signaling pathway is involved in the regulation of cellular functions of osteoclasts and osteoblasts. Suppression of signaling in this pathway by administration of EGFR-TKIs has been used as an option for anticancer therapy in NSCLC patients with activating mutations of the EGFR gene. We describe the case of an NSCLC patient treated with afacitinib in whom we observed a significant suppression of bone remodeling accompanied by an increase in BMD, which was further potentiated by downstream administration of denosumab. The effect of EGFR-TKI inhibition on bone metabolism has not been sufficiently studied. In vitro data show that EGFR inhibition leads to attenuation of osteoblast and osteoclast activity. Further research is also desirable in view of important overlaps into clinical practice (bone metastases, Skeletal-Related Events, OsteoNecrosis of the Jaw).Case reports

Rosa Jan, Fabrik Ivo, Soukup Ondřej, Palička Vladimír

Clin Osteol 2024; 29(3): 80-83 | DOI: 10.36290/clo.2024.010

Kardiovaskulární riziko při léčbě romosozumabemComments

Vrablík Michal

Clin Osteol 2024; 29(3): 77-79

Osteoporosis (OP) is a systemic metabolic disease characterized by reduced bone mass and disturbed bone microarchitecture, which causes increased bone fragility and thus increased risk of fractures even with minimal trauma. The goal of osteoporosis treatment is restitution of thinned bone tissue. The ultimate and main goal is fracture prevention. The effectiveness of treatment can also be judged accordingly. An early, indirect indicator of the success of treatment is an increase in bone density, or at least a slowing of bone loss to the physiological limit. Sclerostin is a protein that in humans is encoded by the SOST gene. Sclerostin is produced mainly by osteocytes and has antianabolic effects on bone formation. Romosozumab is a humanized IgG2 monoclonal antibody against sclerostin. The development of an antibody against sclerostin seemed ideal to affect bone formation precisely because of the almost exclusive expression of the SOST gene in bone. Romosozumab has proven to be extremely effective in increasing bone mineral density (BMD), modulating markers of bone turnover and reducing fracture risk. Treatment with romosozumab results in a rapid and effective reduction in fracture risk in postmenopausal women with osteoporosis. The dual mechanism of action makes romosozumab a unique and effective treatment option for osteoporosis, particularly in cases where rapid increases in bone density are desired. The significant reduction in fracture risk represents a substantial clinical benefit.Review articles

Růžičková Olga

Clin Osteol 2024; 29(3): 55-76 | DOI: 10.36290/clo.2024.008

Niekoľko slov na úvodEditorial

Clin Osteol 2024; 29(3): 53

Sborník abstrakt: XV. celostátní konference Sekundární osteoporóza, Plzeň, 10.-11. 5. 2024Abstracts

Clin Osteol 2024; 29(1-2): 31-50

Výber z najnovších vedeckých informácií v osteológiiLiterature

Šteňová Emoke

Clin Osteol 2024; 29(1-2): 29-30

Acetabuloplasty in therapy of severe dysplasia of the hip: case reportCase reports

Rendek Pavol; Halas Matúš; Kubičková Paulína; Bevilaqua Jana; Kokavec Milan

Clin Osteol 2024; 29(1-2): 25-28 | DOI: 10.36290/clo.2024.004

Developmental dysplasia of the hip (DDH) is a prearthrotic hip defect requiring therapy from neonatal age. The Slovak population has an above-average incidence of DDH, which is why hip screening using the triple-screen method has been introduced in the Slovak Republic. When the most severe form of dysplasia is detected -⁠ hip luxa­tion and obstructions preventing the reposition of the femoral head into the acetabulum, surgical treatment is indicated. During surgery, evacuation of the acetabulum is performed, i.e. removal of all repositioning obstacles. Subsequently, a Dega acetabuloplasty and capsuloplasty are performed. In some cases, the femur...

Treatment by romosozumab in secondary osteoporosis: a review of the literatureReview articles

Brunerová Ludmila

Clin Osteol 2024; 29(1-2): 20-24 | DOI: 10.36290/clo.2024.003

Osteoporosis represents the most common metabolic bone disease, which affects every third woman and every fifth man worldwide. Low-trauma fractures represent the most serious complications of osteoporosis, responsible for significant morbidity, mortality and increased economical costs. Therapy of osteoporosis is based on three pillars -⁠ lifestyle changes, suplementation of vitamin D and calcium and specific antiosteoporotic treatment, which is able to decrease the fracture risk in a half. Romosozumab, a humanized monoclonal antibody against sclerostin has been the most recent anabolic treatment introduced to the Czech market. I tis indicated...

Falls prevention -⁠ identification and intervention of risk factorsReview articles

Greplová Kamila

Clin Osteol 2024; 29(1-2): 12-19 | DOI: 10.36290/clo.2024.002

Falls and fall-related injuries are common in older adults, have negative effects on functional independence and quality of life and are associated with increased morbidity, mortality and health related costs. World guidelines for falls prevention and management for older adults: a global initiative were published in September 2022, which include an algorithm for fall risk stratification and patient assessment. For older people at high risk of falling, multifactorial falls risk assessment should be performed as a basis for subsequent targeted intervention. Examination should focus on history of fall, physical examination including gait assessment,...

System of coordinated care for osteoporotic patients in the Czech RepublicReview articles

Vrablíková Květa, Palička Vladimír, Pikner Richard

Clin Osteol 2024; 29(1-2): 5-11 | DOI: 10.36290/clo.2024.001

Osteoporosis is a population disease with a huge impact on the lives of individuals, but also on the health system. Increasing the proportion of seniors in our population is worsening the sustainability of the current management system of osteoporotic patients. Over the past 3 years, several new projects have been created to handle this situation. A strategy to reduce the number of osteoporotic fractures is being implemented, which involves a comprehensive restructuring of the osteoporotic patient care system as recommended by the International Osteoporosis Foundation (IOF). Recommended diagnostic and therapeutic procedures are updated, projects for...