Několik slov úvodem

prof. MUDr. Vladimír Palička, CSc., Dr.h.c.

Clin Osteol 2025; 30(3): 127

Recommended dual-energy X-ray absorptiometry (DXA) bone densitometry report format

Jan Rosa, Vladimír Palička, Vít Zikán, Petr Kasalický, František Šenk, Richard Pikner, Milan Bayer, Ladislav Bortlík, Ludmila Brunerová, Pavel Horák, Štěpán Kutílek, Václav Vyskočil

Clin Osteol 2025; 30(3): 130-133

Introduction: In the last 2 years the number of DXA bone densitometry devices in the Czech Republic has increased substantially. The number of patients examined and the number of reports of individual DXA studies have increased proportionally. The accuracy and precision of the description is essential for the quality of care of patients with osteoporosis and other osteopathies. No recommended form of DXA examination report has been published in the Czech literature so far. Methods: The key items of the Recommended Format were designed and developed by the SMOS Working Group using literature search and gathering experience from established DXA centres....

Mezioborové stanovisko k bezpečnosti a efektivitě kombinované hormonální antikoncepce s denní dávkou ethinylestradiolu 20 a 30 μg

Česká gynekologicko-porodnická společnost (ČGPS ČLS JEP), Slovenská gynekologicko-porodnická společnost (SGPS) spolu se Společností pro metabolická onemocnění skeletu (SMOS), Spoločnosťou pre osteoporózu metabolické ochorenia kostí (SOMOK), prof. MUDr. Vladimír Palička, CSc., Dr.h.c.

Clin Osteol 2025; 30(3): 134

Chronic low-grade inflammation and primary osteoporosis

Jan Štěpán

Clin Osteol 2025; 30(3): 145-152

Population aging associated with chronic low-grade inflammation and a wide range of diseases is a global public health problem. One such disease is primary osteoporosis. The quantity and quality of bone mass decreases in all people from the fourth decade. In women, this involutional bone loss can be significantly accelerated in the perimenopausal and postmenopausal periods. A decrease in bone quality and mass is associated with changes in the immune system and the persistence of chronic mild inflammation in the bone, muscle, and intestine. With the aging population, early prevention of osteoporosis and low-traumatic fractures becomes urgent. An effective...

Metastatic versus osteoporotic vertebral fractures

Martin Bibza, Peter Tisovský, Boris Šteňo

Clin Osteol 2025; 30(3): 153-160

Differentiating metastatic from osteoporotic vertebral fractures is clinically crucial yet challenging. We summarize key clinical and imaging "red flags" (night pain unrelieved by rest, progression, neurological deficit) and advocate a multimodal diagnostic pathway (MRI, CT; selective PET/CT use). A case initially managed as an osteoporotic fracture illustrates pitfalls of first-line interpretation and the value of image re-evaluation and comprehensive physical examination. Correct recognition of metastatic involvement enabled appropriate staging and subsequent management planning.

Differential diagnostics of back pain

Richard Chaloupka, Luděk Ryba

Clin Osteol 2025; 30(3): 161-166

Diagnostics of back pain consists of several levels - history, subjective, objective examination, imaging methods, laboratory tests, internal and neurological examinations. Each level has to be evaluated, and all levels have to be compared and concluded. In imaging methods we start with X-rays, anteroposterior and lateral. CT examination is indicated in skeletal pathology (especially in injuries). MRI is indicated in neural deficit, suspicion of inflammation and tumours, bone scan in suspicion of metastatic lesions. Laboratory tests: ESR, CRP, blood count help us in infections and internal examination. After diagnosis of affected level (vertebra, disc)...

Prevalence of hand osteoarthritis in NÚRCH patients

Veronika Farská, Soňa Wimmerová, Ivan Rybár

Clin Osteol 2025; 30(3): 136-144

Objective: To determine the prevalence of clinically symptomatic hand osteoarthritis (HOA) among patients examined at NÚRCH Piešťany. Methods: The patient sample (n = 6 319) included individuals evaluated at NÚRCH Piešťany during the first half of 2019. The prevalence of clinically symptomatic HOA and radiographic involvement of specific hand joint sites were assessed, with particular attention given to erosive and trapezioscaphoid osteoarthritis. The results were statistically analyzed using Pearson correlation tests. Results: Among 6 319 outpatients, the prevalence of clinically symptomatic HOA was 15.98 % (1 010 patients). The prevalence of erosive...

A case study: Diagnostic relation of Paget's disease and cardiac transthyretin amyloidosis

Filip Lukačík, Vladimíra Baarová, Klára Mátlová, Richard Pikner

Clin Osteol 2025; 30(3): 167-171

Paget´s disease of bone is a metabolic bone disorder characterised by excessive bone resorption followed by an increase in bone formation of defective bone. Diagnosis is based on laboratory findings of elevated ALP, X­ray and whole body bone scintigraphy. Transthyretin amyloidosis (ATTR) of heart is a storage disease characterised by pathological deposition of transthyretin protein. Specific scintigraphic examination using 99mTc DPD is necessary to confirm ATTR or an endocardial biopsy if needed. Excessive accumulation of bone­seeking radiopharmaceuticals in the myocardium may occur during the whole body bone scintigraphy. This accumulation may point...

Denosumab v léčbě osteoporózy - vysadit či pokračovat

MUDr. Magdalena Agnieszka Sokalska-Jurkiewicz Ph.D.

Clin Osteol 2025; 30(3): 174-176

Kam směřuje léčivý přípravek Prolia po 15 letech na českém trhu?

Clin Osteol 2025; 30(3): 177-181

Latest research and news in osteology

Emőke Šteňová

Clin Osteol 2025; 30(3): 182

Nová éra v léčbě osteoporózy: Terrosa v předplněném peru dostupná i mimo specializovaná osteologická centra

MUDr. Hana Strnadová

Clin Osteol 2025; 30(3): 172