Clin Osteol 2006; 11(1): 28-29
Phosphatonins - factors regulating phosphate metabolismReview articles
Phosphatonins present a recently discovered group of phosphate-regulating factors. These consist of FGF23, MEPE, FRP4. Pivotal role is also played by PHEX. Disease states associated with phosphatonins are X-linked hypophosphatemic rickets (XLH), autosomal dominant hypophosphatemic rickets (ADHR) and tumour-induced osteomalacia (TIO). This review gives basic information on phosphatonins and their effects.
Keywords: phosphate, phosphatonin -hypophosphatemia-FGF 23PHEX, MEPE, FRP4
Published: June 11, 2006 Show citation
References
- Wilkins GE, Granleese S, Hegele RG, et al. Oncogenic osteomalacia: evidence for a humoral phosphaturic factor. J Clin Endocrinol Metab 1995;80:1628-34.
Go to original source... - Jonsson KB, Mannstadt M, Miyauchi A, et al. Extracts from tumors causing oncogenic osteomalacia inhibit phosphate uptake in opossum kidney cells. J Endocrinol 2001;169: 612-20.
Go to original source... - Kumar R. Phosphatonin - a new phosphaturetic hormone? Lessons from tumourinduced osteomalacia and X-linked hypophosphataemia. Nephrol Dial Transplant 1997;12:11-13.
Go to original source... - Shimada T, Mizutani S, Muto T, Yoneya T, et al. Cloning and characterization ofFGF23 as a causative factor oftumor-induced osteomalacia. Proc Natl Acad Sci USA 2001;98:6500-5
Go to original source... - ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associa ted with mutations in FGF23. Nat Genet 2000;26:345^8.
Go to original source... - Silve C, Beck L. Is FGF23 the long sought phosphaturic factor phosphatonin? Nephrol Dial Transplant 2002;17:958-61.
Go to original source... - Tenenhouse HS, Sabagh Z. Novel phosphate-regulating genes in the pathogenesis of renal phosphate wasting disorders. Pflugers Arch - Eur J Physiol 2002; 444:317-26.
Go to original source... - Blumsohn A What have we learnt about the regulation of phosphate metabolism? Curr Opin Nephrol Hypertens 2004;13:397-401.
- Liu S, Guo R, Simpson LG, Xiao Z, Quarles LD. Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J Biol Chem 2003; 278:37419-26.
Go to original source... - Rowe PS.The wrickkened pathways of FGF23, MEPE and PHEX. Crit Rev Oral Biol Med 2004;15:264-81.
Go to original source... - Weber TJ, Liu S, Indridason OS, Quarles LD. Serum FGF23 levels in normal and disordered phosphorus homeostasis. J Bone Miner Res 2003;18:1227-34
Go to original source... - Rowe PS, Garrett IR, Schwarz PM, et al. Surface plasmon resonance (SPF) con firms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for im paired mineralization in X-linked rickets(HYP) Bone 2005;36:33-46.
Go to original source... - Baroncelli GI, Bertelloni S, Sodini F, et al. Genetic advances, biochemical and cli nical features and critical approach to treatment of patients with X-linked hypophosphatemic rickets. Pediatr Endocrinol Rev 2004;1:361-79.
- Cho HY, Lee BH, Kang JH, et al. A clinical and molecular genetic study of hypophosphatemic rickets in children. Pediatr Res 2005;58:329-33.
Go to original source... - Quarles LD. FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. Am J Physiol Endocrinol Metab 2003;285:1-9.
Go to original source... - Velayoudom-Cephise FL, Vantyghem MC, Wemeau JL. Hereditary hypophospha taemia in adults. Presse Med 2005;34:1720-6.
- Dunstan CR, Zhou H, Seibel MJ. Fibroblast growth factor 23: A phosphatonin regulating phosphate homeostasis? Endocrinology 2004;145:3084-6
Go to original source... - White KR, Larsson TM, Econs MJ. The roles of specific genes implicated as cir culating factors involved in normal and disordered phosphate homeostasis: Frp-4, MEPE, and FGF23. Endocr Rev 2006;7:Epub ahead of print.
- Ferrari SL, Bonjour JP, Rizzoli R. Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men. J Clin Endocrinol Metab 2005;90:1519-24.
Go to original source... - Berndt TJ, Schiavi S, Kumar R. "Phosphatonins" and the regulation of phospho rus homeostasis. Am J Physiol Renal Physiol 2005;289:1170-82.
Go to original source... - Yu X, White KE. FGF23 and disorders of phosphate homeostasis. Cytokine Growth Factor Rev 2005;16:221-32.
Go to original source... - White KE, Carn G, Lorenz-Depiereux B, et al. Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23. Kidney Int 2001;60: 2079-86.
Go to original source... - Riminucci M, Collins MT, Fedarko NS, et al. FGF-23 in fibrous dysplasia ofbone and its relationship to renal phosphate wasting. J Clin Invest 2003;112:642-6.
Go to original source...

