Physiology and pathophysiology of phosphorus metabolism - still many questionsOriginal contributions

M. Bayer

Clin Osteol 2006; 11(1): 3-4

Markers of bone remodelling, bone density and endocrine response after polytraumas and burnsCase reports

R. Doleček, L. Pleva, A. Pohlídal, J. Tymonová, M. Kadlčík, T. Karlík, Z. Švagera, R. Závodná

Clin Osteol 2006; 11(1): 5-22

The concept of the Acute Phase Response (APR) is explained. 29 patients after polytraumas (evaluated by ISS criteria) and 28 burned patients (evalu­ ated by their Burn Index, BI) were followed. At regular intervals their bone resorption (ACP, CTX, DPD, PHP) and bone formation (ALP, osteocalcin, PICP) markers were examined as well as iPTH, total and ionized kalcium, inorganic phosphates (iP), 250H vit. D3, testosterone (T), dihydrotestoste­ rone (DHT), free testosterone (FT), cortisol, 17pestradiol, DHEA-S, TNFa, Interleukin-6 (IL-6), IL-8, IL-10 and sIL-2R. The blood samples of the trau­ ma patients were taken at days 1-7-14-28, of the burned at 1-7-14-28-56,...

Hypophasphatemic osteomalaciaReview articles

P Horák, M. Tichý, J. Zadražil

Clin Osteol 2006; 11(1): 24-27

An uncommon case of the acquired form of hypophosphatemic osteomalatia in forty years old lady with hip, ankle and spine pain is presented. The biochemical examination revealed severe hypophosphatemia (0,47 mmol/l) and elevation of the bone specific alkaline phosphatase (3.23 pmol/l). The diagnosis was confirmed by the bone histomorphometry. The therapy with potassium hydrogen phosphate, substitution of calcium and administ­ ration ofvitamin D3 brought the significant improvement ofclinical symptoms and laboratory findings. Authors discuss the differential diagnosis of hy­ pophosphatemia and the pathogenesis of hereditary and acquired forms of hypophosphatemic...

Phosphatonins - factors regulating phosphate metabolismReview articles

S. Kutilek, S. Skálová

Clin Osteol 2006; 11(1): 28-29

Phosphatonins present a recently discovered group of phosphate-regulating factors. These consist of FGF23, MEPE, FRP4. Pivotal role is also played by PHEX. Disease states associated with phosphatonins are X-linked hypophosphatemic rickets (XLH), autosomal dominant hypophosphatemic rickets (ADHR) and tumour-induced osteomalacia (TIO). This review gives basic information on phosphatonins and their effects.

Mediekos Labor, s. r. o.News

P. Novosad, Z. Málek

Clin Osteol 2006; 11(1): 30-31

Osteoporosis - a well hidden threatInformations

J. Jeníček

Clin Osteol 2006; 11(1): 32

Information on the session of the SMOS Board held on 23 January 2006Informations

Clin Osteol 2006; 11(1): 33

Information on the session of the SMOS Board held on 31 March 2006Informations

Clin Osteol 2006; 11(1): 34

News from around the worldLiterature

Clin Osteol 2006; 11(1): 36-39