Clinical Osteology, 2024 (vol. 29), issue 4

Editorial

Několik slov úvodem

prof. MUDr. Vladimír Palička, CSc., dr.h.c.

Clin Osteol 2024; 29(4): 119-120

Review articles

Steroid contraception -⁠ the influence on bone metabolism

Fait Tomáš

Clin Osteol 2024; 29(4): 122-127

The combined hormonal contraception have positive influence on bone mineral density due to its estrogen component. This effect could have clinical application in group of women with menstrual cycle´s disorders and in perimenopausal women. Extremely low doses of ethinylestradiol could forestall the achievement of bone mineral density peak. Depot medroxyprogesterone acetate is not suitable contraception for women with risk of osteoporosis.

Osteoporosis and liver diseases

Košcál Mojmír

Clin Osteol 2024; 29(4): 128-131

Increasing attention to the interaction between liver and bone has stimulated interest in targeted interventions for various forms of osteoporosis. Liver damage induced by various liver diseases can cause imbalances in bone metabolism, suggesting a new regulatory paradigm between liver and bone. However, the role of the liver in the development of osteoporosis is still not well understood. Therefore, investigating the precise regulatory mechanisms (liver-bone) may offer innovative clinical approaches to treat liver and bone-related diseases.

Hemophilia and bone tissue metabolism

Palička Vladimír; Horáčková Jana; Pavlíková Ladislava; Hyšpler Radomír

Clin Osteol 2024; 29(4): 132-135

Findings of reduced bone mineral density and osteoporosis in hemophilia patients are gradually increasing and will certainly increase with successful treatment and increasing life expectancy. Older, not very numerous studies are being replaced by large meta-analyses showing significant reduction of bone mineral density in hemophiliacs. However, it is not only the effect of increasing age that is being demonstrated, but also the direct and indirect pathobiochemical links between coagulation factor deficiency and the effect of their therapeutic administration on bone tissue metabolism. A crucial role is played by the influence of the RANK/RANKL/OPG system...

Case reports

The fragile beauty of bone -⁠ a perspective on fracture risk assessment in clinical practice: a case report

Killinger Zdenko

Clin Osteol 2024; 29(4): 143-146

In Blahoš's lecture, the author points out several aspects of bone quality and the possibilities of their use, not only when determining the risk of fracture, but also when deciding on the need for anti-porotic therapy. Briefly documents the development of diagnostic methods and therapeutic approaches in the last 30 years of Slovak osteology. Author focused on the role of bone densitometry in the diagnostic and therapeutic algorithm and progress in the position of DXA in real practice in the Slovak Republic in the given period. In conclusion, the author on a specific case report pointed out how individual bone quality parameters can influence the decision...

Charcot's osteoarthropathy or Sudeck's Syndrome? A case report

Novák Vladimír

Clin Osteol 2024; 29(4): 147-150

A patient (born in 1950), was examined for suspicion of Sudeck's syndrome of the left foot. The problems arose after prolonged work in the garden -⁠ significant pain in the instep and sole, sensitivity to touch, swelling and redness up to the ankles. There was no previous fracture or other trauma, in the pre-illness the patient was fully mobile without support. Due to the sixteen-year history of type 2 diabetes mellitus, we considered Charcot's osteoarthropathy in the differential diagnosis; Subsequently, three-phase skeletal scintigraphy and MRI of the left foot were compatible with this diagnosis, as they showed pathologically increased activity...

COVID-19 treatment and glucocorticoid-induced osteoporosis: a case report

Štambera Dalibor

Clin Osteol 2024; 29(4): 151-156

This case report describes the case of a patient treated with glucocorticoids in connection with his COVID-19 disease, who was subsequently diagnosed with glucocorticoid-induced osteoporosis (GIOP), the most common type of secondary osteoporosis today, based on densitometric findings and a history of low-strain fracture. The article highlights the need for preventive vitamin D and calcium supplementation during glucocorticoid treatment and also the need to perform whole-body densitometry at prescribed intervals in accordance with relevant recommendations.

Comments

What's (new) in the guidelines of the osteological societies of the German-speaking countries published in 2023

Hess Zdeněk

Clin Osteol 2024; 29(4): 136-142

The 2023 guidelines from German-speaking scientific osteological societies offer updated recommendations for osteoporosis prevention, diagnosis, and treatment, focusing on new risk factors, such as humeral fractures, cardiac and renal insufficiency, and chronic hyponatremia. The guidelines also consider additional factors, like immobility and HIV, and newly define bone density thresholds for initiating treatment. Romosozumab has been added as a therapeutic option to reduce the risk of vertebral and non-vertebral fractures. The improved fracture risk calculator now combines the two strongest risk factors with bone density measurements and shortens the...