Clin Osteol 2015; 20(3): 103-106

Relationship between vitamin D3 and sex hormones in patients with coronary artery diseaseOriginal contributions

A. Bednářová, Z. Zelinková, J. Payer

There have been some reports about possible effects of vitamin D3 on sex hormones levels in males but the results are controversial. The study compared the levels of sex hormones (total testosterone, FAI, FSH and LH) in 72 patients with acute coronary syndrome whose levels of vitamin D3 were sufficient (> 30 pg/L) or insufficient (< 30 pg/L). With increasing age, levels of FAI declined signifi­ cantly. Patients with insufficient vitamin D3 levels had significantly higher levels of FSH and LH compared to those sufficient vitamin D3 levels (8.04 vs 5.5 IU/L, p = 0.027, and 10.5 vs 6.5 IU/L, p = 0.025, respectively). Thus, vitamin D3 insufficiency is associated with "subclinical" or "compensated" hypogonadism.

Keywords: vitamin D3, sex hormones, acute coronary syndrome

Published: December 11, 2015  Show citation

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Bednářová A, Zelinková Z, Payer J. Relationship between vitamin D3 and sex hormones in patients with coronary artery disease. Osteologický bulletin. 2015;20(3):103-106.
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References

  1. Payer J, Killinger Z et al. Osteoporóza, Herba 2012; 1. vydanie: str. 50-53.
  2. Vitezova A, Zillikens C, van Herpt T et al. Vitamin D status and metabolic sy me in the elderly: the Rotterdam Study. Eur J Endocrinol 2014; pii: EJE-14-0580.
  3. Brazdilova K, Dlesk A, Koller T et al. Vitamin D deficiency - a possible link tween osteoporosis and metabolic syndrome. Bratisl Lek Listy 2012;113(7): 412-416. Go to original source...
  4. Pilz S, Dobnig H, Winklhofer-Roob B et al. Low serum levels of 25-hydroxyvitamin D predict fatal cancer in patients referred to coronary angiography. Cancer Epidemiology, Biomarkers and Prevention 2008;17:1228-1233. Go to original source...
  5. Pilz S, März W, Wellnitz B et al. Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients ref red for coronary angiography. Journal of Clinical Endocrinology and Metabolism 2008. Go to original source...
  6. Taheri M, Modarres M, Abdollahi A 189 the effect of vitamin D supplementation on anti-mullerian hormone levels in reproductive-age women. Reprod Fertil Dev 2014;27(1):185-186. Go to original source...
  7. Chang EM, Kim YS, Won HJ et al. Association between sex steroids, ovarian re­ serve, and vitamin D levels in healthy nonobese women. J Clin Endocrinol Metab 2014;99(7):2526-2532. Go to original source...
  8. Hammoud AO, Meikle AW, Paterson CM et al. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl 2012;14(6): 855-859. Go to original source...
  9. Lee DM, Tajar A, Pye SR et al. Association of hypogonadism with vitamin D sta­ tus: the European Male Ageing Study. Eur J Endocrinol 2012;166(1):77-85. Go to original source...
  10. Wehr E, Pilz S, Boehm BO et al. Association of vitamin D sta drogen levels in men. Clin Endocrinol (Oxf). 2010;73(2):243-248. Go to original source...
  11. Pilz S, Frisch S, Koertke H et al. Effect of vitamin D supplementation on test terone levels in men. Horm Metab Res 2011;43(3):223-225. Go to original source...
  12. Hejiboler AC, Oosterwerf M, Schroten NF et al. Vitamin D supplementation and testosterone concentration in male human subjects. Clin Endocrol (Oxf). 2015.
  13. Holick F, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, Treatment and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. The Endocrine Society 2011; p 4. Go to original source...
  14. Payer J, Baňárová A. Vplyv testosterónu na kardiovaskulárne ochorenia u mužov. Vnitř Lek 2010;56(7):702-708.
  15. Bhasin S. et al. Testosterone therapy in adult men with androg dromes. Compendium of Clinical Practice Guidelines 2009; s. 28-46.
  16. Pérez-Fernandez R, Alonso M, Segura C et al. Vitamin D receptor gene ex on in human pituitary gland. Life Sci 1997;60(1):35-42. Go to original source...
  17. Corbett ST, Hill O, Nangia AK. Vitamin D receptor found in human sperm. Urology 2006;68:1345-1349. Go to original source...
  18. Aquila S, Guido C, Perrotta I et al. Human sperm anatomy: ultrastructural loca zation of 1a,25-dihydroxyvitamin D receptor and its possible role in the human male gamete. Journal of Anatomy 2008;213:555-564. Go to original source...
  19. Blomberg Jensen M, Nielsen JE, J0rgensen A et al. Vitamin D receptor and vita­ min D metabolizing enzymes are expressed in the human male reproductive tract. Human Reproduction 2010;25:1303-1311. Go to original source...
  20. Kinuta K, Tanaka H, Moriwake T et. al. Vitamin D is an important factor in es gen biosynthesis of both female and male gonads. Endocrinology 2000;141: 1317-1324. Go to original source...
  21. Blomberg Jensen M, Bjerrum PJ, Jessen TE et al. Vitamin D is positively asso­ ciated with sperm motility and increases intracellular calcium in human sperma­ tozoa. Human Reproduction 2011;26:1307-1317. Go to original source...
  22. Ramlau-Hansen CH, Moeller UK, Bonde JP et al. Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young he­ althy men. Fertility and Sterility 2011;95:1000-1004. Go to original source...
  23. Foresta C, Strapazzon G, De Toni L et al. Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis. Journal of Clinical Endocrinology and Metabolism 2011;96:E646-E652. Go to original source...
  24. Tiwari A. Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder gational Drugs Journal 2009;12:2040-3410.
  25. Wehr E, Pilz S, Schweighofer N et al. Association ofhypovitaminosis D wi tabolic disturbances in polycystic ovary syndrome. European Journal of Endo­ crinology 2009;161:575-582. Go to original source...
  26. Ngo DT, Chan WP, Rajendran S et al. Determinants of insulin responsiven young women: impact of polycystic ovarian syndrome, nitric oxide, and vita­ min D. Nitric Oxide 2011;25:326-330. Go to original source...
  27. Hahn S, Haselhorst U, Tan S et al. Low serum 25-hydroxyvitamin D concentra­ tions are associated with insulin resistance and obesity in women wi ovary syndrome. Experimental and Clinical Endocrinology and Diabetes 2006;114:577-583. Go to original source...
  28. Figurová J, Dravecká I, Petríková J et al. Vitamín D a metabolický s so syndrómom polycystických ovárií. Forum Diabeticum 2014; 3(3):143-148.
  29. Ozkan S, Jindal S, Greenseid K et al. Replete vitamin D stores predict reproduct success following in vitro fertilization. Fertility and Sterility 2009;94:1314-1319. Go to original source...
  30. Somigliana E, P^nina-Bordignon P, Murone S et al. Vitamin D reserve is higher in women with endometriosis. Human Reproduction 2007;22:2273-2278. Go to original source...
  31. Yildirim B, Guler T. 1-alpha,25-dihydroxyvitamin D3 regresses endometriotic im­ plants in rats by inhibiting neovascularization and altering regulation of matrix metalloproteinase. Postgrad Med 2014;126(1):104-110. Go to original source...




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