Relationship between vitamin D3 and sex hormones in patients with coronary artery diseaseOriginal contributions

A. Bednářová, Z. Zelinková, J. Payer

Clin Osteol 2015; 20(3): 103-106

There have been some reports about possible effects of vitamin D3 on sex hormones levels in males but the results are controversial. The study compared the levels of sex hormones (total testosterone, FAI, FSH and LH) in 72 patients with acute coronary syndrome whose levels of vitamin D3 were sufficient (> 30 pg/L) or insufficient (< 30 pg/L). With increasing age, levels of FAI declined signifi­ cantly. Patients with insufficient vitamin D3 levels had significantly higher levels of FSH and LH compared to those sufficient vitamin D3 levels (8.04 vs 5.5 IU/L, p = 0.027, and 10.5 vs 6.5 IU/L, p = 0.025, respectively). Thus, vitamin D3 insufficiency...

Burns and bones (bone changes after burns)Original contributions

R. Doleček, Z. Crkvenjaš-Němečková, L. Pleva, J. Tvrdík, Z. Švagera

Clin Osteol 2015; 20(3): 107-122

Osteoporosis following burns has been repeatedly reported. The main objectives were to monitor 28 various markers in a group of 73 burnt patients (12 females, 61 males) on 7 occasions throughout a year (Days 1, 7, 14, 28, 56, 183 and 365), and to determine which markers could contribute to the development of osteoporosis, with general catabolism in acute phase response (APR) that may be ex­ cessive. So far, there are no clear criteria for such excessiveness although it has been repeatedly shown to exist. For six to twelve months, bone resorption markers such as CTX, NTX, PHP, DPD and, partly, acid phosphatase were significantly in­ creased. For several...

Retrospective study of denosumab treatment in dialysis patientsCase reports

V. Spustová, J. Rosenberger, I. Lajdová, L. Wsolová

Clin Osteol 2015; 20(3): 123-129

Objective: The aim of this retrospective study was to evaluate exp on hemodialysis (CKD 5D) based on available laboratory parameters. Patients and Methods: The study comprised 33 hemodialysis patients from 18 dialysis centers in Slovakia. Patients received a single dose of denosumab and, on a monthly basis, concentrations of calcium, phosphorus and intact parathyroid hormone (iPTH) were mo­ nitored over a period of six months. The da of p < 0.05 were considered significant. Results: Serum calcium concentration significantly decreased at one month after denosumab administration, with 15 patients (45 %) having concentrations 1.8 mmol/L. At the same...

Osteopetrosis - a family with marble bone diseaseNews

Š. Kutílek, T. Hála

Clin Osteol 2015; 20(3): 130-134

Report from the Committee meeting of SMOSNews

Clin Osteol 2015; 20(3): 135-136

Actual Insighst into Endocrine and Genetic Aspects of the SkeletonNews

I. Žofková

Clin Osteol 2015; 20(3): 136