Clin Osteol 2013; 18(2): 39-43

Metabolic bone disease in HIV-pozitive personsOriginal contributions

V. Palička

Metabolic bone diseases are very common in HIV-positive persons. Given the increasing prevalence of HIV-positive persons and their better survival, these disorders will pose a serious problem in caring for these patients. Osteopenia and osteoporosis are significantly more prevalent in HIV-positive persons than in the general population, due to both the viral load itself and significantly more preva­ lent risk factors (low BMI, smoking, alcohol abuse, malabsorption, vitamin D deficiency, viral hepatitis co-infection, hypogonadism and others). Also the retroviral therapy itself usually has a negative impact on bone metabolism. Screening and adequate therapy are recommended in persons with more than one risk factor. Apart from calcium and vitamin D supplements (at doses higher that in the general population), mainly antiresorptive drugs are formation on the use of other drugs for these cases. In addition to osteoporosis, osteomalacia and

Keywords: bone mineral density, fractures, HIV

Published: December 11, 2013  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Palička V. Metabolic bone disease in HIV-pozitive persons. Osteologický bulletin. 2013;18(2):39-43.
Download citation

References

  1. Waters L, Patterson B, Scourfield A, Hughes A, de Silva S, Gazzard B, Barton Asboe D, Pozniak A, Boffito M. A dedicated clinic for HIV-positive individuals over 50 years of age: a multidisciplinary experience. Int J STD AIDS 2012;23/8: 546-552. Go to original source...
  2. Tsai M-S, Hung Ch-Ch, Liu W-Ch, Chen K-L, Chen M-Y, Hsieh S-M, Sheng W-H, Sun H-Y, Shih TTF. Reduced bone mineral density among HIV-infected pa­ tients in Taiwan: prevalence and associated factors. J Microbiol Immunol Infect 2012, doi: 10.1016 (Ahead of print).
  3. Negredo E, Bonjoch A, Gómez-Mateu M, Estany C, Puig J, Perez-Alvarez N, Rosales J, di Gregorio S, del Rio L, Gómez G, Clotet B. Time of Progression to Osteopenia/Osteoporosis in Chronically HIV-Infected Patients: Screening DXA Scan. PLoS One 2012;7(10):e46031. Go to original source...
  4. Paccou J, Viget N, Legrout-Gérot I, Yazdanpanah Y, Cortet B. tients with HIV infection. Joint Bone Spine 2009;76(6):637-641. Go to original source...
  5. Garlassi E, Zona S, Vescini F, Domingues da Silva A, Berardi C, Orlando G, Ca F, Menozzi M, Santoro A, Mussini C, Guaraldi G. Tenofovir accelerates bone mass loss of the lumbar spine in the first years of menopause in HIV-infected women. J Int AIDS Soc 2012;15(6):18317. Go to original source...
  6. Rothman MS, Bessesen MT. HIV Infection and Osteoporosis: Pathophysiology, Diagnosis, and Treatment Options. Curr Osteoporos Rep 2012;10(4):270-277. Go to original source...
  7. Bunders MJ, Frinking O, Scherpbier HJ, van Arnhem LA, van Eck-Smit BL, Kuijpers TW, Zwinderman AH, Reiss P, Pajkrt D. Bone Mineral Density Increases in HIV-Infected Children Treated With Long-term Combination Antiretroviral Therapy. Clin Infect Dis 2013;56(4):583-586. Go to original source...
  8. Vikulina T, Fan X, Yamaguchi M, Roser-Page S, Zayzafoon M, Guidot DM, Ofotokun I, Weitzmann MN. Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats. Proc Natl Acad Sci 2010; 107(31): 13848-13853. Go to original source...
  9. Rifas L, Weitzmann MN. A Novel T Cell Cytokine, Secreted Osteoclastogenic Factor of Activated T Cells, Induces Osteoclast Formation in a RANKLIndependent Manner. Arthrit Rheum 2009;60(11):3324-3335. Go to original source...
  10. Gedmintas L, Solomon DH: HIV and its effects on bone: a primer for rheumato­ logists. Curr Opin Rheumatol 2012;24(5):567-575. Go to original source...
  11. Goorney BP, Lacey H, Thurairajasingam S, Brown JDK. Avascular necrosis ofthe hip in a man with HIV. Genitourin Med 1990;66(6):451-452. Go to original source...
  12. Staňková M, Skokanová V. Historie a perspektivy antiretrovirové terapie i HIV/AIDS. Remedia 2007;17(2):175-180.
  13. De Carvalho EH, Gelenske T, Bandeira F, de Albuquerque MFPM. Bone mineral density in HIV-infected women taking antiretroviral therapy: a systematic rev Arq Bras Endocrinol Metab 2010;54(2):133-142. Go to original source...
  14. Cotter AG, Powderly WG. Endocrine complications of human immunodeficiency virus infection: Hypogonadism, bone disease and ten Pract Res Clin Endocrinol Metab 2011;25(3):501-515. Go to original source...
  15. Guidelines of the European AIDS Clinical Society, version 6, October 20. www.europeanaidsclinicalsociety.org
  16. Cotter AG, Mallon PWG. Therapeutic Options for Low Bone Mineral Density in HIV-Infected Subjects. Curr HIV/AIDS Rep 2012;9(2):148-159. Go to original source...




Clinical Osteology

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.