Metabolic bone disease in HIV-pozitive personsOriginal contributions

V. Palička

Clin Osteol 2013; 18(2): 39-43

Metabolic bone diseases are very common in HIV-positive persons. Given the increasing prevalence of HIV-positive persons and their better survival, these disorders will pose a serious problem in caring for these patients. Osteopenia and osteoporosis are significantly more prevalent in HIV-positive persons than in the general population, due to both the viral load itself and significantly more preva­ lent risk factors (low BMI, smoking, alcohol abuse, malabsorption, vitamin D deficiency, viral hepatitis co-infection, hypogonadism and others). Also the retroviral therapy itself usually has a negative impact on bone metabolism. Screening and adequate...

Comparison of fracture risk in postmenopausal women in Slovakia and the neighboring countriesOriginal contributions

E. Némethová, Z. Killinger, J. Payer

Clin Osteol 2013; 18(2): 44-47

More than half of fragility fractures occur in patients with osteopenia and effort is given to identifying these high-risk patients. For this purpose, the FRAX tool was developed that calculates absolute 10-year fracture risks. The FRAX is calibrated to epidemiological da­ ta of each country. If it is not available for a specific country, the use of a surrogate country model with similar epidemiological data is recommended. Variability among several countries can lead to significant differences in patient counts in treatment initiation. Aim of the study: To compare the proportion of patients indicated for antiosteop with the Slovak version of FRAX...

Effect of liver regeneration on bone metabolism in adult male Wistar ratsOriginal contributions

K. Doubková, I. Gradošová, K. Švejkovská, P. Živný,

Clin Osteol 2013; 18(2): 48-52

Objective: The study aimed at d healthy adult male Wistar rats. Material and methods: Rats were distribute into 5 groups of 8 animals each. The first group were controls with no abdominal surge­ ry. Animals in the second (24LAP) and third (24PH) groups underwent laparotomy and 70% partial hepatectomy, respectively, and were sacrificed 24 hours after the procedure. Animals in groups four (72LAP) and five (72PH) underwent laparotomy and 70% partial he­ patectomy, respectively, and sacrificed 72 hours after the procedure. ELISA was used to determine the bone formation markers pro­ collagen type I N-terminal prope gen (CTx) in the obtained serum. Results:...

Risk factors for osteoporosis and the importance of FRAX for primary care physiciansOriginal contributions

S. Tomková, B. Suchá, P. Jackuliak

Clin Osteol 2013; 18(2): 53-59

Osteoporosis is a disease that may be reliably diagnosed, treated and prevented. Improved diagnosis and treatment of osteoporosis should be an important priority of primary care physicians. The article is concerned with a survey of primary care physicians' gene­ ral knowledge of osteoporosis and their awareness of densitometry indications. The general knowledge was ascertained using a ques­ tionnaire on risk factors, drugs and diseases associated with osteoporosis as well as the prevalence and mortality of the condition. The results showed relatively poor general knowledge. There were statistically insignificant differences in knowledge depending on...

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Clin Osteol 2013; 18(2): 60-63

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