Clin Osteol 2012; 17(1): 14-20

Diagnosis, prevention and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD): KDIGO guideline and subsequent initiatives of national and multinational working groupsReview articles

S. Dusilová Sulková

The article states the basic principles of the 2 ney disease-mineral and bone disorder (CKD-MBD). The definition and characteristics of CKD-MBD were first introduced in 2006. It represents a new perspective on renal bone disease, taking into consideration pathophysiological and clini vascular system in chronic kidney disease and failure. The guideline is supported by defined target concentrations of laboratory markers (serum levels of calcium, phosphorus, parathor­ mone and calcidiol) in individual stages of chronic kidney disease (CKD), including dialysis patients (CKD 5D) and transplantation patients (CKD T). It includes evaluation techniques focused on renal osteodystrophy in the narrower sense of the word and the vas­ cular component of CKD-MBD. Additionally, the basic principl final part defines the main directions of clinical research. As compared with the previous KDOQI text, the KDIGO guideline provides some new approaches. In particular, emphasis is put on the assessment of laboratory and other findings in time and relations (a dynamic approach), and the need for cooperation between cli­ nical facilities and laboratories. From a clinical practice perspective, it is im available examination methods.

Keywords: chronic kidney disease, renal osteodystrophy, CKD-MBD, KDIGO, guideline

Published: June 11, 2012  Show citation