Clin Osteol 2008; 13(4): 172-174

Claudin-16 and claudin-19 and their roles in mineral homeostasisReview articles

S. Skálová, ©. Kutilek

Claudins are transmembrane tight junction proteins. They determine the barrier properties of intercellular contact existing between the two neighbouring cells and control the selectivity of paracellular transport. Claudins can therefore significantly affect mineral ho­ meostasis. Claudin-16 (CLDN16) and claudin-19 (CLDN19) regulate the paracellular transport of calcium and magnesium in the loop of Henle. Claudin-16 is defective in autosomal recessive familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC), resulting in renal insufficiency Mutations in CLDN19 lead to FHHNC, renal failure and severe ocular abnormalities. This review provides basic information on CLDN16 and CLDN19 and on the clinical manifestations of CLDN16 a

Keywords: claudin-16, claudin-19, hypercalciuria, nephrocalcinosis, hypermagnesiuria, hypomagnesaemia

Published: December 11, 2008  Show citation

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Skálová S, Kutilek ©. Claudin-16 and claudin-19 and their roles in mineral homeostasis. Osteologický bulletin. 2008;13(4):172-174.
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