Clin Osteol 2007; 12(2): 70-73
Vitamin D and other parameters of calcium and phosphate metabolism in healthy term newborns after birthGuidelines
Background: The literature concerning vitamin D saturation in newborns is sparse. The levels of vitamin D in healthy term newborns in the Czech Republic have not been examined yet. Vitamin D saturation in newborns depends mainly on matern pregnancy that may be decreased due to nutritional habits and climatic conditions in the Central Europe.
Objective: To get comparative values for bone metabolism assessment in newborns with very low birth weight.
Design: A prospective study carried out in the spring period (from April toJune 2006) in a cohort of 28 healthy term Caucasian new borns with normal birth weight (limits 3 000-4 000g). Blood and urine samples were drawn at the age of 3-7 days for examination of 25-hydroxyvitamin D (25/OH/D), calcium (Ca), phosphate (P), alkaline phosphatase (ALP), osteocalci (PTH) in serum and calcium and phosphate in urine. Parental informed written consent was obtained.
Results: Though other parameters of calcium and phosphate metabolism were in normal ranges. However, levels of 25/OH/D were considerably lower than reference values for this age group as stated in the literature. A 25/OH/D and OC levels and a negative (but not significant) correlation of 25/OH/D and PTH.
Conclusion: Term newborns in the Czech Republic are born with an insufficient supply of vitamin D in the spring period obviously. The significant correlation of 25/OH/D level with bone formation marker (OC) and the tendency to higher PTH concentrations in newborns with lower 25/OH/D levels support the pre ment.
Keywords: vitamin D, newborn, skeletal development
Published: December 11, 2007 Show citation
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