Několik slov úvodem

prof. MUDr. Vladimír Palička, CSc., Dr.h.c.

Clin Osteol 2026; 31(2): 71

Kost a hormonální vlivy v průběhu života

prof. MUDr. Tomáš Fait, Ph.D.

Clin Osteol 2026; 31(2): 72

Progestin only contraception and bone health

Vlasta Dvořáková

Clin Osteol 2026; 31(2): 76-77 | DOI: 10.36290/clo.2026.010

Progestin only contraception is often chosen for women with a higher cardiovascular risk. The intrauterine system with levonorgestrel is completely neutral to bone metabolism. Progestin only pills with desogestrel or drospirenone also have no negative effect on bone health. In contrast the use of depot medroxyprogesterone acetate reduces bone mineral density.

Menopausal hormone therapy and bone health

Lukrécia Tatárová

Clin Osteol 2026; 31(2): 78-82 | DOI: 10.36290/clo.2026.011

Menopause is a physiological phase in a woman's life that is associated not only with the occurrence of vasomotor and urogenital symptoms, but also with significant long term health consequences, particularly affecting skeletal, cardiovascular, and cognitive health. Declining estrogen levels lead to accelerated bone loss, which may result in the development of osteoporosis. Menopausal hormone therapy (MHT) represents the most effective treatment for vasomotor symptoms and the genitourinary syndrome of menopause, while also serving as an effective strategy for the prevention of postmenopausal bone loss. Numerous randomized controlled trials and metaanalyses...

Tibolone and the bone health

Tomáš Fait

Clin Osteol 2026; 31(2): 84-86 | DOI: 10.36290/clo.2026.012

Hormone replacement therapy is the most effective treatment for acute climacteric syndrome and prevention of chronic changes from estrogen deficiency. Tibolone as a selective regulator of tissue estrogenic activity is the only alternative of comparable efficacy with an excellent safety profile. It achieves better results in the area of influencing the psyche and sexuality of postmenopausal women and in some safety parameters (reduces mammographic density). Its effect on bone health is comparable to hormone replacement therapy.

Anorexia nervosa and bone health

Pavla Jelínková

Clin Osteol 2026; 31(2): 87-90 | DOI: 10.36290/clo.2026.013

Mental anorexia represents a serious psychiatric disorder with significant somatic complications. One of the most serious is a disorder of bone metabolism leading to a decrease in bone mineral density, disruption of bone microarchitecture, and an increased risk of fractures. Adolescence is a critical period for the accumulation of bone mass and the achievement of peak bone density. Energy deficit and hormonal dysregulation lead to disruption of the physiological process of bone formation and remodeling, resulting in a lifelong increased risk of osteoporosis. The aim of this review article is to summarize current knowledge on the pathophysiology of...

Gynecologists in caring for bone health in women with breast cancer

Stefánia Faitová, Tomáš Fait

Clin Osteol 2026; 31(2): 91-96 | DOI: 10.36290/clo.2026.014

Breast cancer is the most common malignancy in women. Therapeutically induced hypoestrogenism may lead to significant bone loss and a consequent increase in fracture risk. Antiresorptive treatment of osteoporosis (bisphosphonates and denosumab) plays an important role in mitigating bone loss induced by anticancer therapy. Currently, evidence supports the use of bisphosphonates as adjuvant therapy to prevent metastasis and recurrence of the disease. Unfortunately, bone health care in women with breast cancer is often not prioritized, leaving this group of patients vulnerable to significant bone loss and subsequent fractures.

Spinal fractures in ankylosing spondylitis

Luděk Ryba, Richard Chaloupka, Dominik Parížek

Clin Osteol 2026; 31(2): 105-110 | DOI: 10.36290/clo.2026.016

Ankylosing spondylitis (AS, Morbus Bechterew) is a chronic inflammatory disease of the axial skeleton leading to progressive spinal ankylosis and secondary osteoporosis. The combination of a rigid spine and impaired bone quality markedly increases the risk of spinal fractures, which often occur even after low-energy trauma. These fractures are typically highly unstable, involve all three spinal columns, and are associated with a significant risk of neurological complications and increased mortality. Conservative treatment is frequently burdened by secondary displacement and failure of immobilization, therefore surgical stabilization represents the...

Lesions of the anterior cruciate ligament in children and adolescents

Matúš Halas, Pavol Rendek, Paulína Kubíčková, Jana Bevilaqua, Martina Frištáková, Milan Kokavec

Clin Osteol 2026; 31(2): 111-115 | DOI: 10.36290/clo.2026.017

Anterior cruciate ligament (ACL) injuries in children and adolescents are among the most common types of knee injuries associated with dynamic sports activities. Incorrect treatment and inappropriate choice of surgical technique can lead to further damage to the knee joint, possibly to the development of secondary osteoarthritis. This work is based on the author's dissertation and the aim of this work is to summarize current knowledge and options for surgical treatment of ACL lesions in children and adolescents.

The impact of patient adherence on the efficacy of osteoporosis pharmacotherapy

Mária Kolesárová, Ľudmila Pavlíková, Dana Marcinčáková, Zuzana Mačeková, Dalibor Kolesár, Ladislav Seman, Ján Kyselovič

Clin Osteol 2026; 31(2): 97-104 | DOI: 10.36290/clo.2026.015

Background: Clinical trials demonstrate that osteoporosis pharmacotherapy reduces fracture incidence by approximately 50%. However, this therapeutic benefit may be severely compromised by sub-optimal patient adherence in real-world clinical practice. The primary objective of this retrospective study was to evaluate the long-term efficacy of osteoporosis pharmacotherapy and assess patient adherence levels using the ADEOS-12 questionnaire, with a specific focus on analysing the correlation between adherence scores and objective clinical outcomes, including bone mineral density (BMD) and biochemical bone turnover markers. Methods: Medication adherence...

Latest research and news in osteology

Emőke Šteňová

Clin Osteol 2026; 31(2): 117-118