Effect of anorexia nervosa on bone metabolism

Čagalová Alžbeta, Tichá Ubica, Killinger Zdenko, Podracká Udmila

Clin Osteol 2020; 25(1): 37-43

Anorexia nervosa is the third most common chronic illness in adolescent girls. Clinical symptoms develop most frequently during sexual maturity. It is a period, when deprivation of nutrients with hormonal dysregulation can disrupt bone formation with microarchitectonic and structural changes and decrease bone mineral density. Objective: The aim of this study was to evaluate bone metabolism and hormonal changes in girls with ano­re­xia nervosa. Patients and methods: There were 65 girls with anorexia nervosa between 10-18 years of age enrolled in this study. We divided the patients into 2 groups: Z-score BMI > -2 SD (A), Z-score BMI ≤ -2 SD (B)....

Early non-responders in teriparatide therapy: retrospective analysis

Masaryk Pavol; Letkovská Alexandra

Clin Osteol 2020; 25(1): 45-49

Teriparatide (TPTD) is a potent osteoanabolic drug. A potential drawback associated with teriparatide treatment is a failure of effect. The incidence of non-responders depends on the definition of lack of response to treatment, baseline bone density, duration of treatment, prior antiresorptive therapy, and measurement accuracy. In our study, we analyzed "early non-responders" after 6 and 12 months of treatment in a group of 306 patients. We identified 36 (11.7 %) patients as early non-responders, of whom 18 after 6 months of treatment and 18 after one year of treatment. There were only 4 men and up to 32 women in the sample, but the percentage of non-responders...

Prevencia sekundárnych fraktúr: multiodborové konsenzuálne stanovisko ku klinickým odporúčaním - komentár k pretlači

Kužma Martin; Payer Juraj

Clin Osteol 2020; 25(1): 6

Prevence sekundárních fraktur: multioborové konsenzuální stanovisko ke klinickým doporučením

Conley B Robert, Adib Gemma, Robert; Adler, Kesson E Kristina, Alexander M Ivy, Amenta C Kelly, Blank D Robert, Brox Timothy William, Carmody E Emily, Chapman-Novakofski Karen, Clarke L Bart, Cody M Kathleen, Cooper Cyrus, Crandall J Carolyn, Dirschl R Douglas, Eagen J Thomas, Elderkin L Ann, Fujita Masaki, Greenspan L Susan, Halbout Philippe, Hochberg C Marc, Javaid Muhammad, Jeray J Kyle, Kearns E Ann, King Toby, Koinis F Thomas, Koontz Scott Jennifer, Kužma Martin, Lindsey Carleen, Lorentzon Mattias, Lyritis P George, Michaud Boehnke Laura, Miciano Armando, Morin N Suzanne, Mujahid Nadia, Napoli Nicola, Olenginski P Thomas, Puzas Edward J, Rizou Stavroula, Rosen J Clifford, Saag Kenneth, Thompson Elizabeth, Tosi L Laura, Tracer Howard, Khosla Sundeep, Kiel P Douglas

Clin Osteol 2020; 25(1): 7-27

Management of osteoporosis and calcium metabolism disorders during COVID-19 pandemics

Smaha Juraj; Kužma Martin; Jackuliak Peter; Killinger Zdenko; Payer Juraj

Clin Osteol 2020; 25(1): 28-34

During the COVID-19 crisis it is very important for people with osteoporosis and calcium metabolism disorders to prevent fractures and to have guidance and support in managing their diseases. Osteologists have to make rapid changes to services in order to help prevent spread of the virus while maintaining best clinical practice possible. Non-urgent appointments should be postponed, remote consultations should be promoted and patients should be empowered to self-manage their conditions safely. Management of patients on specific parenteral antiporotic treatments could be problematic. IV bisphosphonates infusions can be delayed for at least 6-9 months...

Doporučení pro pacienty s osteoporózou v době pandemie COVID-19

Zikán Vít

Clin Osteol 2020; 25(1): 35-36

Atypical cases of secondary hyperparathyroidism in patients with kidney disease and failure: case reports

Pokorná Anita, Horáček Jiří, Vávrová Jaroslava, Chrobok Viktor, Čelakovský Petr, Šafránek Roman, Ryba Miroslav, Řehořková Pavla, Pavlíková Ladislava, Palička Vladimír, Sulková Dusilová Sylvie

Clin Osteol 2020; 25(1): 50-57

The text is focused on clinical and laboratory manifestations of secondary hyperparathyroidism, associated with chronic kidney disease and chronic renal failure. Presenting four our case reports, we demonstrate not only the complex and complicated "traditional" SHPT pathogenesis associated with kidney disease, but also others involving and contributing factors and problems. First, in some patients, it may be difficult to properly recognize between primary and secondary hyperparathyroidism. Additionally, the role of vitamin D deficiency as the crucial factor in parathyroid gland stimulation is demonstrated. Also, the role of dialysis solution composition...