Egg shellArticles

K. Míková

Clin Osteol 2003; 8(2): 31-32

Thyroid hormones and boneArticles

L. Baqi, J. Payer, Z. Killinger

Clin Osteol 2003; 8(2): 33-43

Thyroid hormones have a crucial role in development of bones during fetal period, bone modulation in childhood and in remodelling cycles in adult hood. Sufficient exposure to thyroid hormones is necessary for normal skeletal development. Thyroid hormone is necessary for the recruitment and maturation of bone cells. Deficienty of thyroid hormones production in utero and in the neonate retards growth and delays skeletal maturation. The presence of thyroid hormone increases bone remodelling. Excess thyroid hormone alters the hormonal regulation of calcium metabolism and can con­ tribute to bone loss. Hyperthyroidism accelerates bone turnover and shortens...

Monitoring changes in bone density using a mathematical model of bone resorption and remodellingArticles

I. Žofková, M. Hill

Clin Osteol 2003; 8(2): 44-46

The authors suggest a method to assess the impact of factors of the inner and external environment and their combinations and the effect of treatment on bone density, as also to predict the risk of osteoporosis using a mathematical model of bone resorption and remodelling. They also suggest the ela­ boration of software, which on the basis of evaluation and its findings would propose the best possible prevention and treatment for each individual patient.

Current approach to hyperphosphataemia in patients with end stage renal diseaseArticles

S. Sulková, F. Svára, M. Fortová, M. Válek

Clin Osteol 2003; 8(2): 47-51

Patients with end stage renal disease (ESRD) frequently suffer from an imbalance of phosphorus and calcium and are frequently diagnosed with hy­ perphosphataemia, caused by inadequate excretion of blood phosphorus by the kidney. Progressive decrease in glomerular filtration rate (GFR) leads to a progressive increase in blood phosphorus level. Hyperphosphataemia and current interventions are suggested to be the basis for multiple comor­ bidities in ESRD patients on chronic haemodialysis. Increased blood phosphorus levels lead to an increase in calcium-phosphorus ion product and con­ sequent soft tissue calcifications.The current treatment of hyperphosphataemia...

Total serum alkaline phosphatase activity and its relationship to age and growth in childrenArticles

Š. Kutílek, E. Márová, J. Barcalová, M. Bayer

Clin Osteol 2003; 8(2): 52-55

Serum activity of alkaline phosphatase (S-ALP) has been used for many years as a marker of bone metabolism. During childhood up to 90% of total S­ ALP is of skeletal origin. Our aim was to evaluate the total S-ALP values in a pediatric reference population and to look for relationship between total S-ALP and growth rate. We obtained age-dependent values of total ALP for boys (n = 363) and girls (n = 347) aged 0 to 16 years . We observed highest S-ALP within the first two years of life in both sex, with another S-ALP peak in boys at the age of 7 years. There was a tendency toward higher S-ALP which failed to reach statistical significance in boys aged...

The structural and functional pattern of vascular bed of the osteochondral junction in femoral heads of mature rabbitsArticles

E. Klika, S. Havelka

Clin Osteol 2003; 8(2): 56-61

Light and electron microscopical study of osteochondral junction (OCHJ) was carried out in three mature rabbits. The mineralized extracellular mat­ rix (MEM) of the calcified layer of articular cartilage is firmlyjoined with the osseous tissue of bone ends. The firm connection of both components is based on a system of arciform processus of MEM dipped into the subchondral bone. On the other hand, vascular channels penetrate from subchond­ ral bone into the MEM. Vascular channels are encapsulated by a thin mantle of osseous tissue. The terminal vascular net originating in bone marrow and dipped into the MEM of OCHJ is formed by blood sinusoids. The...

JUBILEEPersonalia

P. Broulík

Clin Osteol 2003; 8(2): 62

Abstracts from abroad, IOF NewsLiterature

Clin Osteol 2003; 8(2): 63-69

CONGRESS ANNOUNCEMENTSInformations

Clin Osteol 2003; 8(2): 70