Clin Osteol 2019; 24(1): 5-13

Effect of vitamin K on musculoskeletal health in postmenopausal womenReview articles

Rosa Jan1, Stančíková Mária2
1 Osteocentrum Affidea Praha, s. r. o.
2 Národný ústav reumatických chorôb Piešťany

Vitamin K plays an important role not only in blood clotting, but also in the regulation of mineralization of bones and cartilage. It appears that vitamin K needs for musculoskeletal health are higher than currently recommended daily doses that are optimal for vitamin K1 but suboptimal for vitamin K2. Epidemiological and observational studies have shown that low vitamin K content in the diet and/or serum is associated with the risk of fracture and osteoarthritis in elderly. However, the randomized controlled intervention trials with vitamin K supplementation in Caucasian population are not convincing regarding the increase in bone mineral density at important regions of interest. Combination of vitamin K and D appears to be effective in osteoporosis. Long-term randomized controlled clinical trials with a large number of subjects and well-defined criteria for bone and joint health are required to confirm current observations.

Keywords: osteoporosis; osteoarthritis; bone; cartilage; vitamin K

Received: May 6, 2019; Accepted: June 3, 2019; Published: June 11, 2019  Show citation

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Jan R, Stančíková M. Effect of vitamin K on musculoskeletal health in postmenopausal women. Clinical Osteology. 2019;24(1):5-13.
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