Clin Osteol 2017; 22(2): 44-50

Influence of biocomposite calcium phosphate materials on the biomechanical dynamics of healing of experimental defect of the compact boneGuidelines

A. Korenkov

Objective: This study was aimed at establishing the influence of different by composition and manufacturer biocompo­ site calcium phosphate materials on the biomechanical dynamics of healing of experimental defect of the compact bone tissue.

Materials and Methods: The experiment was carried out on 48 white Wistar rats. In the middle third of the diaphysis of the femur there was reproduced the perforated defect with a diameter of 2.5 mm to medullar channel, which in the animals of the first group was filled with biocomposite calcium phosphate material "Collapan" (hydroxyapatite/collagen/antibiotic), and in the animals of the second group with "Easy-graft™CRYSTAL" (hydroxyapatite/P-tricalcium phosphate). The fragments of injured bones were examined at the 15th, 30th, 60th and 120th day by the method of dynamic microindentation with determining of the microhardness and Young's modulus of the site of implantation of calcium phosphate material and the adjacent to it maternal bone.

Results: It is established that throughout the duration of the experiment, the microhardness and Young's modulus of the site of implantation of "Collapan" and "Easy-graft™CRYSTAL" were gradually approaching the same indicators of the maternal bone. 30th and 60th day of the experiment, the area of implantation of "Collapan" by microhardness and Young's modulus exceeded the area of implantation of "Easy-graft™CRYSTAL", and on the 120th day they did not just equal among themselves, but also exceeded the corresponding indicators of the maternal bone.

Conclusions: The biocomposite calcium phosphate materials "Collapan" and "Easy-graft™CRYSTAL" from a biome­ chanical point of view, contribute to complete healing of the defect of the compact bone tissue in 4 months.

Keywords: reparative osteogenesis, hydroxyapatite, P-tricalcium phosphate, collagen, microhardness, Young's modulus

Published: December 11, 2017  Show citation

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Korenkov A. Influence of biocomposite calcium phosphate materials on the biomechanical dynamics of healing of experimental defect of the compact bone. Osteologický bulletin. 2017;22(2):44-50.
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