Clin Osteol 2015; 20(1): 10-14

Depression and osteoporosisReview articles

L. Brunerová

The relationship between depression and osteoporosis is reciprocal. Depressed patients show lower bone mineral density and a higher fracture risk due to their "unhealthy" lifestyle, higher risk of falls, use of antidepressant medication and hormonal and mediator chan­ ges (particularly of the serotonergic system). Among antidepressants, selective serotonin reuptake inhibitors (SSRIs) are thought to be associated with the highest risk for osteoporosis. The risk of fracture steeply increases after treatment initiation due to vegetative disturbances; after adjustment of the autonomic nervous system, the risk slightly increases with the length of the treatment due to the impact of SSRIs on bone mineral density mediated by the serotonergic system. On the contrary, osteoporosis complications could aggravate depression symptoms. The relationship between depression and osteoporosis may imply some practical recommendations for screening of osteoporosis in selected subgroups of depressed patients and osteologists should inquire about SSRI treatment when considering secondary pharmacology-induced osteoporosis.

Keywords: depression, serotonin, SSRI, BMD, osteoporosis, fracture

Published: June 11, 2015  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Brunerová L. Depression and osteoporosis. Osteologický bulletin. 2015;20(1):10-14.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Becker DJ, Kilgore ML, Morr Rheumatol Rep 2010;12:186-191.
    2. Cooper C, Jacob F, Chinn C. Fracture incidence and changes in quality women with an inadequate clinical outcome from osteoporosis therapy: the Observational Study of severe Osteoporosis (OSSO). Osteoporosis Int 2008;19:493-501. Go to original source...
    3. Johnell O, K 16:Suppl 2:3-7.
    4. Nevitt M, Ettinger B, Black D. The association of radiographically detected ver­ tebral fractures 1998;128:793-800.
    5. Dempster DW. Osteoporosis and the b J Manag Care 2011; 17:Suppl 6:164-169.
    6. Bareš M, Kopeček M. Úvod do biologické léčby rezistentní depresivní poruc Psychiat. pro praxi 2006;6:276-280.
    7. Pratt LA, Brody DJ. Depression in the United States household population, 2005-2006. NCHS Data Brief 2008;7:1-8. Go to original source...
    8. Cizza G, Primma S, Coyle M, Gourgiotis L, Csako G. Depression and osteoporo­ sis: a research synthesis with meta-analysis. Horm Metab Res 2010;42:467-482. Go to original source...
    9. Reid KJ, Harker J, Bala MM. Epidemiology of chronic non-cancer pain in Eur narrative review of prevalence, pain treatments and pain impact. Curr Med Res Opin 2011;27:449-462. Go to original source...
    10. Salaffi F, Cimmino MA, Malavolta N. The burden of prevalent fractures on health-related quality of life in postmenopausal women with osteoporosis: the IMOF study. J Rheumatol 2007;34:1551-1560.
    11. Coelho R, Silva C, Maia A. Bone mineral de study in women. J Psychosom Res 1999;46:29-35. Go to original source...
    12. Silverman SL, Shen W, Minshall ME, Xie S, Moses KH. Prevalence of de ve symptoms in postmenopausal women with low bone mineral density and/or prevalent vertebral fracture: results from the Multip Evaluation (MORE) study. J Rheumatol 2007;34:140-144.
    13. Wu Q, Magnus JH, Liu J, Bencaz AF, Hentz JG. Depression and low bone mine­ ral densit 1309-1320.
    14. Yirmiya R, Bab I. Major depression is a risk factor for low bone mineral densi a meta-analysis. Biol Psychiatry 2009;66:423-432. Go to original source...
    15. Atteritano M, Lasco A, Mazzaferro S. Bone mineral density, quantitative ultra­ sound parameters and bone metabolism in postmenopausal women with depres­ sion. Intern Emerg Med 2013;8(6):485-491. Go to original source...
    16. S0gaard AJ, Joakimsen RM, Tverdal A, F0nneb0 V, Magnus JH, Berntsen GK. Long-term mental distress, bone mineral density and non-vertebral fractures. The Tromso Study. Osteoporos Int 2005;16:887-897.
    17. Kamholz B, Unutzer J. Depression after hip fracture. J Am Geriatr Soc 2007;55:126-127. Go to original source...
    18. Mamplekou E, Bountziouka V, Psaltopoulou T. Urban environment, physical in­ activity and unhealthy dietary habits correlate to depression among elderly living in eastern Mediterranean islands: the MEDIS (MEDiterranean ISlands Elderly) study. J Nutr Health Aging 2010;14:449 455. Go to original source...
    19. Koster JB, Kuhbauch BA Psychiatr 2011;53:561-565.
    20. Michelson D, Stratakis C, Hill L on. N Engl J Med 1006;335:1176-1181. Go to original source...
    21. Faridhosseini F, Sadeghi R, Farid L, Pourgholami M. Celecoxib: a new augmen­ tation strategy for depressive mood episodes. A systematic review and met lysis of randomized placebo-controlled trials. Hum Psychopharmacol. 2014; 29(3):216-223. Go to original source...
    22. Licinio J, Wong ML. The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to n toxicity and neuroprotection. Mol Psychiatry 1999;4:317-327. Go to original source...
    23. Blumenfeld O, Williams FM, Valdes A, Hart DJ, Malkin I, Spector TD, Livshits G. Association of interleukin-6 gene polymorphisms with hand osteo­ arthritis and hand osteoporosis. Cytokine 2014;69(1):94-101. Go to original source...
    24. Pérez-López FR. Vitamin D and its implic women: an update. Maturitas 2007;58:117-137. Go to original source...
    25. Lee DM, Tajar A, O'Neill TW. Lower vitamin D levels are associ pression among community-dwelling European men. J Psychopharmacol 2011;25:1320-1328. Go to original source...
    26. P^re CM. Treatment of depression. Lancet 1965;1(7392):923-925. Go to original source...
    27. Bliziotes M. Update in Serotonin and Bone. J Clin Endocrinol Metab 2010; 4124-4132. Go to original source...
    28. Ducy P, Karsenty G. The two faces of serotonin in bone biology. JCB 2010;191(1):7-14. Go to original source...
    29. Krishnan V, Bryant HU, Macdougald OA Regulation of bone mass by Wnt signaling. J Clin Invest 2006;116:1202-1209. Go to original source...
    30. Diem SJ, Blackwell TL, Stone KL, Yaffe K, Haney EM, Bliziotes MM, Ensrud KE. Use of antidepressants and rates of hip bone loss in older wom of osteoporotic fractures. Arch Intern Med 2007;167(12):1240-1245. Go to original source...
    31. Haney EM, Chan BK, Diem SJ, Ensrud KE, Cauley JA, Barrett-Connor E, Orwoll E, Bliziotes MM. Osteoporotic Fractures in Men Study Group. Association of low bone mineral density with selective serotonin reuptake inhibitor use by olde Arch Intern Med 2007;167(12):1246-1251. Go to original source...
    32. Bonnet N, Bernard P, Beaupied H, Bizot JC, Trovero F, Courteix D, Benhamou CL. Various effects of antidepressant drugs on bone microarchitecture, mechanical properties and bone remodeling. Toxicol Appl Pharmacol 2007; 221(1):111-118. Go to original source...
    33. Vestergaa 9(1):137-141.
    34. Verdel BM, Souverein PC, Egberts TC, van Staa TP, Leufkens HG, de Vries F. Use of antidepressant drugs and risk of osteoporotic and non-osteoporotic frac res. Bone 2010;47(3):604-609. Go to original source...
    35. Ziere G, Dieleman JP, van der Cammen TJ, Hofman A, Pols HA, Stricker BH. Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures. J Clin Psychopharmacol 2008;28(4): 411-417. Go to original source...
    36. Wu Q, Bencaz AF, Hentz JG, Crowell MD. Selective serotonin reuptake inhibitor treatment and risk of fractures: a meta-analysis of cohort and case-control stu Osteoporos Int 2012;23(1):365-375. Go to original source...
    37. Ramasubbu R, Taylor VH, Samaan Z. The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management ofpatients with mood disorders and select comorbid medical conditions. Ann Clin Psychiatry 2012;24:91-109. Go to original source...
    38. Haney EM, Warden SJ, Bliziotes MM. Effects of selective serotonin reuptake in­ hibitors on bone health in adults: time for vention and management? Bone 2010;46:13-17. Go to original source...
    39. Aloumanis K, Mavroudis K. The "depressive" face of osteoporosi porotic" face of depression. Hormones (Athens) 2013;12(3):350-362. Go to original source...

    Return to the content


    Clinical Osteology

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.