Clin Osteol 2013; 18(1): 9-15
Serum concentrations of vitamin D and bone markers and their relationship to rheumatoid arthritis activityReview articles
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disorder also affecting the extra-articular systems. Patients with RA are known to have significantly reduced bone mass and to develop osteoporosis subsequently. The exact contribution of high in flammatory activity and vitamin D3 concentration to this the process is unclear.
Objective: The study aimed at determining metabolism and vitamin D3 concentrations.
Patients and methods: A total of 43 patients with different RA activity were examined. Their mean age was 52.4 years and the female-to-male ratio was 3.3 : 1. The patients were treated with neither anti-osteoporotic drugs nor vitamin D. Their disease activity was evaluated using the disease activity score (DAS 28) and bone metabolism was determined by laboratory markers such as osteocalcin (OC) and C-terminal telopeptide o correlation coefficient was used.
Results: There was a statistically significant negative correlation between disease activity and vitamin D levels. The relationship bet ween bone markers and DAS 28 scores increased RA activity was observed.
Conclusion: RA is one of the most typical examples of chronic inflammation. Profound bone changes are known to occur within a re latively short time in patients with high RA activity. Therefore, secondary osteoporosis screening should be provided in this group of patients. A recommended clinical approach includes vitamin D, bone
Keywords: rheumatoid arthritis, DAS 28, osteocalcin, CTx, vitamin D
Published: June 11, 2013 Show citation
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