Clin Osteol 2011; 16(3): 87-95

Vitamin D - state-of-the-art knowledge, effect and role in human medicineNews

P. Novosad, P. Hrdý, P. Fojtík

Vitamin D is one of the oldest hormones, having been produced by life forms for over 750 million years. Phytoplankton, zooplankton and most animals that are exposed to sunlight have the capacity to produce vitamin D. In humans, vitamin D is critically important for the development, growth and maintenance of a healthy body, from birth until death. Intensive research is underway in many me­ dicinal disciplines or clinical diagnoses. Current medical research of vitamin D is considered very important.

Keywords: vitamin D, metabolism, hydroxylation, molecular level, receptor, target organ

Published: December 11, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Novosad P, Hrdý P, Fojtík P. Vitamin D - state-of-the-art knowledge, effect and role in human medicine. Osteologický bulletin. 2011;16(3):87-95.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Bikle D 1770-1773.
    2. Bikle DD, Nemanic MK.,Whitny O., Elias PW. Neonatal human foreskin kerati cytes produce 1.25-dihydroxyvitamín D3. Biochemistry 1986;8:25(7):1545-1548. Go to original source...
    3. Yasuda T. Clin Calcium 2009;19(1):109-116. Go to original source...
    4. Pugliese MT, Blumberg DL, Hl J Am Coll Nutr 1998;17:637-641. Go to original source...
    5. Wagner CL, Greer FR. Prevention of rickets and vitamin D children, and adolescents. Pediatrics 2008;122(5):1142-1152. Go to original source...
    6. Feldman D, Malloy PJ. Hereditary 1.25-dihydroxyvitamin D resistant rickets: lecular basis and implications for the role of 1.25(OH)2D3 normal physiology. Mol Cell Endocrinol 1990;72:C57-C62. Go to original source...
    7. Hughes, MR. Malloy PJ, O'Malley B W, Pike JW, Feldman D. Genetic defects of the 1.25-dihydroxyvitamin D3 receptor. J Recept Res 1999;11:699-716. Go to original source...
    8. Malloy PJ, Pike JW, Feldman D. Hereditary 1.25-dihydroxyvitamin D resistant rickets. In: Feldman D, Glorieux F., Pike JW Vitamin D, (eds). Academic Pess, San Diego, CA, 2000; pp.756-788.
    9. Holick MF. McCollum. Award Lecture: Vitamin D-new horizons the 21st. centu­ ry. Am J Clin Nutr 1994;60:619-630. Go to original source...
    10. Makin G, Lohnes D, Byford V, Ray R, Jones G. Target cell metabolism of 1.25dihydroxyvit 262:173-180.
    11. Evans RM 240:889-895.
    12. Horst RL, Kozsewski NJ, Reihardt TA 1alfa-Hydroxylation of 24-hydroxyvitamin D2 represent a minor physiological pat mammals. Biochemistry 1990;29:578-582. Go to original source...
    13. Holick MF, Biancuzzo RM, Chen TC et al.Vitamin D2 is as effective as vi D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 2008;93:677-681. Go to original source...
    14. McKenna NJ, O'Malley BW. An issue of tissues: dividing the split of selective estrogen receptor modulators. Nat Med 2000;6(9):960-962. Go to original source...
    15. Christakos S, Dhawan P, Liu Y, et al. New min D action. J Cell biochem 2003;88:695-705. Go to original source...
    16. Rastinejad FT, Perlmann RM, Sigler PB. Structural determina ceptor assembly on DNA direct repeats. Nature 1995;375:203-211. Go to original source...
    17. Svarem K, Bergseth S, Oftebro H, Pedersen JI. Subcellular localiz D3 25-hydroxylation in human liver. J Biol Chem 1984;259:10936-10946. Go to original source...
    18. Sone T, Ozono K, Pike JW. A 55-kilodalton accesory factor facilitates vit receptor binding. Mol Endocrinol 1991;5:1578-1586. Go to original source...
    19. Whitfield GK, Hsieh JC, Nakajima S, MacDonald PN et al. A higly conserved region in the hormone-binding domain of the human vitamin D receptor contains residuem vital for heterodimerization with retinoid tional activation. Mol Endocrinol 1995;9:1166-1179. Go to original source...
    20. Zechel C, XQ Shen, JY Chen, et al. The dimerization interfaces formel the DNA binding domains of RXR, RAR and TR determine the binding specifi­ city and p 1425-1433.
    21. Institute of Medicine Washington. Dietary Reference Intakes for calcium., 2010. Posted: 11/11/2010, US Pharmacist 2010; Jobson Publishing. www.iom.edu/Activities/Nutrition/DRIVitDCalcium.aspx.Acceseed
    22. Holick MF. Vitamin D deficiency. Engl J Med 2007;357(3):266-281. Go to original source...
    23. Holick MF. Vitamin D, importance in the prevention of cancers, type 1 diabe heart disease, and osteoporosis. Am J Clin Nutr 2004;79(3):362-371. Go to original source...
    24. Bikle DD, M.D., Ph.D. - Profesor of Medicine, University of Kalifornia - VA Medical Center, 4150 Clement St.(111N), San Francisco, CA Vitamin D, Chapter 3, 2008; Production, Metabolism and Mechanisms of Action.
    25. Holick MF. Vitamin D: a D-Lightful health perspective. Nutr Rev 2008;66 (10 Suppl 2):S182-194. Go to original source...
    26. Blanco JCG, Wang IM et al. Transcription factor TFIIB and the vitamin D recep­ tor cooperatively activate ligand-dependent transcription. Proc Natl Acad Sci 1995;92:1535-1539. Go to original source...
    27. Blunt JW, DeLuca HF, Schnoes HK. 25-Hydroxycholecalciferol. A biologically active metabolite of vitamin D3. Biochemistry 1968;7:3317-3322. Go to original source...
    28. Cali JJ, Russell DW. Characterization of human sterol 27-hydroxylase. A mi chondrial cytochrome P-450 that catalyzes multiple oxidation reactions in bile acid biosynthesis. J Biol Chem 1991;266:7774-7778. Go to original source...
    29. Chambon P. A 1996;10:940-954.
    30. Christakos SR, Gill S, Lee H. Li. Molecular aspects of the calbidins. J Nutr 122:678-682.
    31. Darwish HM, DeLuca HF. Recent advances in the molecular biology of vitamin D action. Prog. Nucleic Acid Res Mol Biol 1996;53:321-344. Go to original source...
    32. DeLuca HF. Vitamin D: metabolism and function. In: Monographs on Endokrinology, edited by F. Gross, M. M. Grombach et al. New York: Sprinter­ Verlag, 1979; pp1-78.
    33. DeLuca HF, Schnoes HK. Metabolism in mechanism of action of vitamin D3. Ann Rev Biochem 1976;45:631-666. Go to original source...
    34. Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1968; 240:889-895. Go to original source...
    35. Feldma pp.1-1285.
    36. Jin CH, Pike JW. Human vitamin D receptor-dependent transactivation in Saccharo 196-205.
    37. Lohnes D, Jones G. Further metabolism of 1.25-dihydroxyvitamin D3 in target cells. Proceedings of the First international Congress on Vitamins an in Life Science. J Nutr Sci 1992; Vitaminol. Special Issue: pp.75-78. Go to original source...
    38. Madhok TC, DeLuca HF. Characteristics of the rat liver microsomal enzyme sys­ tem converting cholecalciferol to 25-hydroxycholecalciferol. Evidence for par pation of cytochrome P-450. Biochem J 1979;184:491-499. Go to original source...
    39. Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell 1995;83:841-850. Go to original source...
    40. Munder M, Herzerberg IM, Zierold C et al. Identification of the porcine inte accesory factor that enables DNA sequence recognition by vitamin D receptor. Proc Natl Acad Sci USA 1995;92:2795-2799. Go to original source...
    41. Rotkiewitz P, Sicinska W, Kolinsky A, DeLuca HF. Model of three-dimensional structure of vitamins D receptor and its binding mechanism with 1-alpha-25-dihydroxyvitamin D3. Proteins 2001;44:188-191. Go to original source...
    42. Bikle D. Vitamin D. Production, Metabolism and mechanism of Action. Ed 2009; University of California.
    43. Holick MF. Vitamin D-Physiology molecular Biology and clinical aplications, Humana Press, New Jersey 1999; pp.1-17. Go to original source...
    44. Malloy PJ, Pike JW, Feldman D. The Vitamin D Receptor and the Syndrome of Hereditary 1.25-dihydroxyvitamin D-Resistant Rickets. Endocrine Reviews 1999; 20(2):156-188. Go to original source...
    45. Renton P. Radiology of rickets, osteomalatia and hypothyreoidism. Hosp Med 1998;59(5):399-403.

    Return to the content


    Clinical Osteology

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.