Clin Osteol 2010; 15(1): 3-8

Effect of high-protein diet and high-glutamine diet on bone metabolism in ratsOriginal contributions

K. Josefová, I. Gradošová, H. Živná, K. Doubková, M. Holeček, P. Živný, V. Palička

The aim of this study was to investigate the effect of high-protein and high-glutamine diet on bone metabolism in rats. Matherial and methods: Male Wistar rats were divided into 3 groups of 6 animals and for 16 weeks were fed different diets. 1. group (KO): standard laboratory diet (SLD), 2. group (HPD): high-protein diet with casein, 3. group (GLN): glutamine-enriched diet. We assayed marker of bone resorption - C terminal telopetide of collagen I (ICTP) and markers of bone formation- osteocalcin (OC) and N-terminal propeptide of procollagen al energy X-ray absorptiometry (DXA).

Results: Concentration of ICTP significantly (p < 0.05) decreased by 33 % in GLN vs. KO. Concentration of OC, PINP and BMD in tail de cantly.

Conclusion: GLN and HPD groups had decreased markers of bone turnover which contributed to decreased in tail BMD.

Keywords: glutamine, osteocalcin, N-t density

Published: June 11, 2010  Show citation

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Josefová K, Gradošová I, Živná H, Doubková K, Holeček M, Živný P, Palička V. Effect of high-protein diet and high-glutamine diet on bone metabolism in rats. Osteologický bulletin. 2010;15(1):3-8.
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