Clin Osteol 2008; 13(4): 158-162

Calciphylaxis: a rare but serious complication of chronic renal failureReview articles

M. Válek

Calciphylaxis is a rare but serious complication accompanying chronic renal disease. Calcification of the tunica media and prolifera­ tion of the tunica intima of small arteries result in the development of difficult-to-heal necrosis of the skin and subcutaneous tissue. Such patients most commonly die of sepsis. The aetiology of calciphylaxis is unknown; however, numerous risk factors have been de­ scribed, with impaired calcium-phosphate metabolism being the most important one. The article summarizes what is known about pa­ thogenesis, clinical course, risk factors and new options for treating the disease.

Keywords: calciphylaxis, chronic renalfailure, dialysis, calcium-phosphate metabolism

Published: December 11, 2008  Show citation

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Válek M. Calciphylaxis: a rare but serious complication of chronic renal failure. Osteologický bulletin. 2008;13(4):158-162.
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