Clin Osteol 2007; 12(4): 156-163
Case report - prolonged hypercalcaemia with an elevated ALP level - the risks and implications for the patientCase reports
The report presents a case of prolonged hypercalcaemia due to advanced primary hyperparathyroidism, with significantly negative implications for the patient, and the initially misleading differential diagnosis of the condition. Hypercalcaemia is a severe mineral imbalance with potentially fatal consequences for patients. The symptoms and signs include: ne urological and muscle dysfunction, mental changes, impaired renal function with all the consequences including renal failure, nep hrolithiasis, extraosseous calcifications, digestive tract diseases, hypertension and, last but not least, myocardial dysfunction potenti ally leading to systolic cardiac arrest. In chronic hypercalcaemia, differential diagnosis should consider primary hyperparathyroidism (PHP). This condition is evidenced by simultaneously elevated alkaline phosphatase (ALP) and parathormone (PTH), hypercalciuria, and imbalanced levels of phosphates in serum and urine. The case report suggests the necessity of early detection of parathyroid pa thology and restored phosphate-calcium (P-Ca) homeostatis.
Keywords: Hypercalcaemia, alkaline phosphatase, parathormone, primary hyperparathyroidism, phosphocal cium metabolism.
Published: December 11, 2007 Show citation
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