Clin Osteol 2007; 12(3): 112-115

The analgesic effect of calcitoninReview articles

I. Kučerová

The analgesic effect of calcitonin (CT) is used mainly in the treatment of acute osteoporotic vertebral fractures. It significantly relie­ ves the pain already in the first week of treatment and improves the patients' quality of life. Less often, it is indicated in Paget's disea­ se, pain in metastatic bone diseases, and algodystrophy. The article gives a concise overview of possible mechanisms of the analgesic effect of CT and deals with its use in the above-mentioned conditions.

Keywords: calcitonin, bone pain, analgesic mechanism ofaction, osteoporosis, vertebralfracture, bone metasta­ ses, Paget's disease, algodystrophy.

Published: December 11, 2007  Show citation

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Kučerová I. The analgesic effect of calcitonin. Osteologický bulletin. 2007;12(3):112-115.
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    References

    1. Braga PC. Calcitonin and its antinociceptive aktivity: Animal and human inves gations 1975-1992. Agents Actions 1994;41:121-131. Go to original source...
    2. Blahoš J. Kalcitonin. In: Blahoš J. Osteoporóza. Galén 1995;53-62.
    3. Gennari C, Agnusdei D, Camporeale A Use of Calcitonin in theTtreatment of Bo­ ne Pain Associated with Osteoporosis. Calcif Tissue Int 1991;49,Suppl 2:S9-S13. Go to original source...
    4. Gennari C. Analgesic Effect of Calcitonin in Osteoporosis. Bone 2002;5,Suppl 5:67S-70S. Go to original source...
    5. Podichetty VK, Segal AM, Liber M, Mazanec DJ. Effectiveness of Salmon Calci­ tonin Nasal Spray in the Treatment of Lumbar Canal Stenosis:A Double-Blind, Randomized, Placebo-Controlled, Paralel Group Trial. Spine 2004;21:2343-2349. Go to original source...
    6. Silverman SL, Azria M. The Analgesic Role of Calcitonin Following Osteoporo­ tic Fracture. Osteoporos Int 2002;13:858-867. Go to original source...
    7. Ofluoglu D, Akyuz G, Unay O, Kahan O. The effect of calcitonin on B-endorphin levels in postmenopausal osteoporotic patiens with back pain. Clinical Rheumato­ logy 2007;26:44-49. Go to original source...
    8. Azria M. Possible Mechanism of the Analgesic Action of Calcitonin. Bone 2002;5:80S-83S. Go to original source...
    9. Lyritis GP, Trovas G. Analgesic Effects of Calcitonin. Bone 2002;5:71S-74S. Go to original source...
    10. Knopp JA, Diner BM, Blitz M et al. Calcitonin for treating acute pain of osteo rotic vertebral compression fractures: a systematic review of randomized, control­ led trials. Osteoporos Int 2005;16:1281-1290. Go to original source...
    11. Yoshimura M. Analgesic mechanism of calcitonin. J. Bone Miner Metab 2000;18:230-233. Go to original source...
    12. Blau LA, Hoehns JD. Analgesic Efficacy of Calcitonin for Vertebral Fracture P^in. The Annals of Pharmacotherapy 2003;4:564-570. Go to original source...
    13. P^padokostakis G, Damilakis J, Mantzouranis E. et al. The effectiveness of cal tonin on chronic back pain and daily activities in postmenopausal women with os­ teoporosis. Eur Spine J. 2006;3:356-362. Go to original source...
    14. Mehta NM, Malootian A, Gilligan JP. Calcitonin for Osteoporosis and Bone P^in. Current Pharmaceutical Design, 2003;9:2659-2676. Go to original source...
    15. Tsavaris N, Kopterides P, Kosmas Ch et al. Analgesic activity of high-dose int venous calcitonin in cancer patients with bone metastases. Oncology Reports 2006; 16:871-875. Go to original source...
    16. Singer FR. Clinical Efficacy of Salmon Calcitonin in Paget's Disease of Bone. Calcif Tissue Int 1991;49 (Suppl 2):S7-8. Go to original source...
    17. Selby PL, Davie MWJ, Ralston SH, Stone MD. Guidelines on the Management of Paget's Disease of Bone. Bone 2002;3:366-373. Go to original source...
    18. Sahin F, Yilmaz F, Kotevoglu N, Kuran B. Efficacy of salmon calcitonin in kom­ plex regional pain syndrome (type 1) in addition to physical therapy. Clin Rheu­ matol 2006;25:143-148. Go to original source...
    19. Appelboom T. Calcitonin in Reflex Sympathetic Dystrophy Syndrome and Other Painful Conditions. Bone 2002;5:84S-86S. Go to original source...
    20. Pferez RSGM, Kwakkel G, Zuurmond WWA, De Lange JJ. Treatment of Reflex Sympathetic Dystrophy (CRPS Type 1): A Research Synthesis of 21 Randomized Clinical Trials. Journal of Pain and Symptom Management 2001;6:511-526. Go to original source...
    21. Gobelet C, Waldburger M, Meier JL. The effect of adding calcitonin to physical treatment reflex sympathetic dystrophy. Pain 1992;48:171-175. Go to original source...
    22. Reuben SS. Preventing the Development of Complex Regional P^in Syndrome af­ ter Surgery. Anesthesiology 2004;101:1215-24. Go to original source...
    23. Marx C, Wiedersheim P, Michel BA, Stucki G. Preventing Recurrence of Reflex Sympathetic Dystrophy in Patients Requiring an Operative Intervention at the Si­ te of Dystrophy after Surgery. Clin Rheumatol 2001;20:114-118. Go to original source...

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