Clin Osteol 2006; 11(2-3): 43-47
The relationship between vitamin D concentration and bone mineral densityNews
Aims: Vitamin D plays an important role in the normal bone mineralization and its deficiency is a risk factor for osteomalacia and osteoporosis. Vita min D deficiency negatively impairs calcium and phosphate metabolism and trigger parathyroid hormone (PTH) increase. Low levels of vitamin D, calcium and phosphate have also been linked to increase in hip fractures in elderly women. The aim of this study was to evaluate relationship between bone mineral density (BMD) and serum levels of 25-hydroxyvitamin D (25 OHD) and 1,25-dihydroxyvitamin D (1,25 OHD) in postmenopausal women.
Methods: This retrospective study included 157 postmenopausal Caucasian women, age 38-79. BMD (g/cm2) was measured at the lumbar spine (L1-L4) and proximal femur using the Hologic Delphi A DEXA densitometer. Osteocalcin and PTH concentrations were determined by monoclonal competitive enzyme immunoassay (EIA, Modular Roche E170), bone-specific alkaline phosphatase by METRA BAP EIA kit. Ionized calcium were de termined by ion-selective electrode. Radioimmunoassay was used to measure vitamin 25 OHD and 1,25 OHD. Statistical analyses were performed using SigmaStat 3.1 (Jandel Scientific Corporation, San Rafael, CA, USA), test used were linear regression and Pearson correlation.
Results: Obtained results showed correlation between vitamin 25 OHD and 1,25 OHD (r = 0.232, p = 0.008) and between calcium and ionized calcium (r = 0.831, p = 0.001). Correlation analyses showed lack of correlation between lumbar spine BMD and concentration 1,25 OHD (r = -0.143, p = 0.119), between proximal femur BMD and 25 OHD (r = 0.113, p = 0.224), as well between BMD and osteocalcin and PTH concentrations.
Conclusions: We did not find correlation between BMD measurement, vitamin D and all investigated bone markers that indicates possible impaired balance between bone formation and bone resorption in postmenopausal women. Some authors concentration is the result of pathological conditions with renal impairment.
Keywords: vitamin D, bone mineral density, osteocalcin, parathyroid hormone, correlation Osteologický bulletin 2006;11(2-3):43-47
Published: December 11, 2006 Show citation
References
- Reginster JY, Lecart MP, Richy F. Importance of alfacalcidol in clinical con tions characterized by high rate of bone loss, J Rheumatol Suppl 2005;76:21-25.
- Orimo H, Schacht E. The D-hormone analog alfacalcidol: the pioneer beyond the horizon of osteoporosis treatment, J Rheumatol Suppl 2005;76:4-10.
- Peacock M. Effect of calcium and vitamin D insufficiency on the skeleton, O porosis International 1998;8:S45-S51.
Go to original source... - Budak N, Cicek B, Sahin H, Tutus A Bone mineral density and serum 25-hydroxyvitamin D level: is there any diference according to dressing style of the fe le university students? Int J Food Sci Nutr 2004;55:569-575. Go to original source...
- Hatun S, Islam O, Cizmecioglu F, Kara B, Babaoglu K, Berk F, Tokalo AS. Subclinical vitamin D deficiency is increased in adolescent girls who wear concea clothing. J Nutr 2005;135:218-222. Go to original source...
- Bultink IE, Lems WF, Kostense PJ, Dijkman BA, Voskuyl AE. Prevalence of and risk factors for low bone mineral density and vertebral fractur systemic lupus erytematosus. Arthritis Rheum 2005;55:2044-2050. Go to original source...
- Gulati S, Sharma RK, Gulati K, Singh U, Srivastava A Longitudinal follow-up of bone mineral density in children with nephrotic syndrome and the role and vitamin D supplements. Nephrol Dial Transplant 2005;20:1598-1603. Go to original source...