Clin Osteol 2004; 9(4): 130-135

The dominant influences accelerating or retarding the changes in cortical densityReview articles

M. Petrtýl, J. Danešová

Limit cycles of bone remodelling are regulated biomechanically and biochemically (genetically). The speeds of biochemical reactions (i.e. the speeds of intense metabolic processes) depend on the volume changes of molecular mixtures and on the stress changes in a bone element. Processes of densi­ ty depend on both the dominant volume changes of molecular mixtures and stress changes. The resultant speed of the j-th biochemical reaction, which forms part of biochemical (metabolic) processes in the bone tissue (in the remodelling limit cycle) is dependent on the product of speeds of the bio­ chemical reaction initiated biochemically (resp. genetically) and on the speeds of chemical reaction initiated biomechanically. The j-th biochemical re­ action is influenced by the internal - primary chemical (genetical) effects and the external - biomechanical effects, i.e. stress changes Ap. The density of bone can be increasing when the stress changes in bone have the positive signum. The dynamic stress/strain changes in bone play the dominant ro­ le at both the thickening and thinning processes. The presented results are useful for clinical purposes.

Keywords: biomechanics, biochemics, corticalis, gro me changes, retardation/acceleration of bone density.

Published: December 11, 2004  Show citation

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Petrtýl M, Danešová J. The dominant influences accelerating or retarding the changes in cortical density. Osteologický bulletin. 2004;9(4):130-135.
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