EditorialEditorial

V. Palička

Clin Osteol 2010; 15(3): 87

Osteoporosis drugs selectively affect bone strenght parameters: dual effect of strontium ranelateReview articles

P. Ammann

Clin Osteol 2010; 15(3): 88-90

Bone strength is determined by biomechanical parameters such as bone mass, size, shape and tissue quality. Many osteoporosis treat­ ments build bone mass but also change tissue quality. Careful investigation of all determinants of bone strength should be considered in the pathophysiology of osteoporosis and consequently in the selection of proper antiosteoporotic treatment.

Increased serum parathyroid hormone concentration with normal serum calcium levels in patients operated for primary hyperparathyroidismReview articles

O. Nývltová, D. Nováková

Clin Osteol 2010; 15(3): 92-94

The article is concerned with the etiology of a postoperative increase in serum parathyroid hormone (PTH) level in patients success­ fully operated for primary hyperparathyroidism (HPT) who have normal postoperative calcium levels. Most authors agree on this being secondary HPT due to hypovitaminosis D and hungry bone syndrome [1]. It is contributed to by metabolic primary HPT and restricted calcium intake in the preoperative period, resulting in skeletal demineralization. Other works, however, relate secondary HPT in p bone metabolism markers, bone density and race. Recurrent and persistent hyperparathyroidism account for approximately 1-2 % of cases...

The parathyroid hormone circadian rhythm and its role in bone metabolismReview articles

M. Luchavová, V. Zikán

Clin Osteol 2010; 15(3): 95-100

The circadian rhythm of parathyroid hormone (PTH) is well established in healthy subjects; however, its role in bone metabolism and factors controlling its physiology need to be clarified. The underlying rhythm of PTH is endogenous and external factors such as nu­ tritional, endocrine or neural factors can modulate its amplitude. In postmenopausal osteoporosis, the circadian rhythm of PTH is blunted and abnormalities in the PTH secretion pattern are observed. Restoration of endogenous PTH rhythm by modifying the hor­ monal environment or nutritional manipulation using timed calcium and phosphate loads may be important for stimulation of bone formation....

Role of leptin in metabolic processes during prenatal and early postnatal lifeReview articles

P. Veselá, M. Bayer

Clin Osteol 2010; 15(3): 102-104

Leptin is a cytokine-like hormone encoded by the ob (obese) gene located on chromosome 7. It is composed of 167 amino acids. The hormone is secreted by a number of cells, including chondrocytes, osteoblasts and placenta cells (adipocytes are the main sour­ ce). It influences bone metabolism during prenatal life, by binding to receptors on ventromedial hypothalamic neurons, osteoblasts and chondrocytes. There is a positive correlation between serum levels of leptin and IGF-1 (insulin-like growth factor 1) in cord blood and the ponderal index (relationship between birth weight and height). It is higher in the blood of newborns with high birth weight....

NEWSNews

Clin Osteol 2010; 15(3): 105

Prof. Rajko Doleček celebrated his 85th birthdayNews

J. Marek

Clin Osteol 2010; 15(3): 106

Prof. MUDr. Jan Štěpán, DrSc. celebrated his 70th birthdayPersonalia

J. Škrha

Clin Osteol 2010; 15(3): 107

13th Congress Slovak and Czech OsteologistsAbstracts

Clin Osteol 2010; 15(3): 109-132