Clin Osteol 2017; 22(4): 142-145

Predictive value of microRNAs in the diagnosis and prognosis of heart failure and osteoporosisReview articles

M. Kužma, A. Gažová, J. Kyselovič, P. Jackuliak, Z. Killinger, J. Payer

The review aimed to present recent findings from clinical studies on micro-RNAs (miRNAs) to better characterize the pathoetiology of heart failure, osteoporosis and sarcopenia, and to possibly even find miRNA targets which would increase the level and accuracy of prediction of the progression and/or treatment of both diseases.

Keywords: osteoporosis, fractures, mikro-RNA, heartfailure

Published: December 11, 2017  Show citation

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Kužma M, Gažová A, Kyselovič J, Jackuliak P, Killinger Z, Payer J. Predictive value of microRNAs in the diagnosis and prognosis of heart failure and osteoporosis. Osteologický bulletin. 2017;22(4):142-145.
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References

  1. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB et al. Heart disease and stroke statistics - 2012 update: a report from the American Heart Association. Circulation 2012;125(1): e2-e220.
  2. Tanko LB, Christiansen C, Cox DA, Geiger MJ, McNabb MA, Cummings SR. Relationship between osteoporosis and cardiovascular disease in postmenopausal women. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 2005;20(11):1912-1920. Go to original source...
  3. van Diepen S, Majumdar SR, Bakal JA, McAlister FA, Ezekowitz JA Heart failure is a risk factor for orthopedic fracture: a population-based analysis of 16,294 patients. Circulation 2008; 118(19):1946-1952. Go to original source...
  4. Frost RJ, Sonne C, Wehr U, Stempfle HU. Effects of calcium supple­ mentation on bone loss and fractures in congestive heart failure. Euro­ pean journal of endocrinology 2007;156(3):309-314. Go to original source...
  5. Sennerby U, Melhus H, Gedeborg R, Byberg L, Garmo H, Ahlbom A et al. Cardiovascular diseases and risk of hip fracture. Jama 2009; 302(15):1666-1673. Go to original source...
  6. Carbone L, Buzkova P, Fink HA, Lee JS, Chen Z, Ahmed A et al. Hip fractures and heart failure: findings from the Cardiovascular Health Study. European heart journal 2010;31(1):77-84. Go to original source...
  7. Gerber Y, Melton LJ, 3rd, Weston SA, Roger VL. Osteoporotic fractu­ res and heart failure in the community. The American journal of medi­ cine 2011;124(5):418-425. Go to original source...
  8. Lyons KJ, Majumdar SR, Ezekowitz JA The unrecognized burden of osteoporosis-related vertebral fractures in patients with heart failure. Circulation Heart failure 2011;4(4):419-424. Go to original source...
  9. Majumdar SR, Ezekowitz JA, Lix LM, Leslie WD. Heart failure is a clinically and densitometrically independent risk factor for osteo­ porotic fractures: population-based cohort study of 45,509 subjects. The Journal of clinical endocrinology and metabolism 2012;97(4): 1179-1186. Go to original source...
  10. Mazziotti G, Baracca M, Doga M, Porcelli T, Vescovi PP, Giustina A Prevalence of thoracic vertebral fractures in hospitalized elderly patients with heart failure. European journal of endocrinology 2012; 167(6):865-872. Go to original source...
  11. Pfister R, Michels G, Sharp SJ, Luben R, Wareham NJ, Khaw KT. Low bone mineral density predicts incident heart failure in men and women: the EPIC (European Prospective Investigation into Cancer and Nutrition) - Norfolk prospective study. JACC Heart failure 2014;2(4): 380-389. Go to original source...
  12. Bekfani T, Pellicori P, Morris DA, Ebner N, Valentova M, Steinbeck L et al. Sarcopenia in patients with heart failure with preserved ejection fraction: Impact on muscle strength, exercise capacity and quality of life. International journal of cardiology 2016;222:41-46. Go to original source...
  13. McFarlane SI, Muniyappa R, Shin JJ, Bahtiyar G, Sowers JR. Osteoporosis and cardiovascular disease: brittle bones and boned arte­ ries, is there a link? Endocrine 2004;23(1):1-10. Go to original source...
  14. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75(5):843-854. Go to original source...
  15. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009;136(2):215-233. Go to original source...
  16. Lee EJ, Baek M, Gusev Y, Brackett DJ, Nuovo GJ, Schmittgen TD. Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. Rna 2008;14(1):35-42. Go to original source...
  17. Pencheva N, Tavazoie SF. Control of metastatic progression by microRNA regulatory networks. Nature cell biology 2013;15(6): 546-554. Go to original source...
  18. Meiri E, Mueller WC, Rosenwald S, Zepeniuk M, Klinke E, Edmonston TB et al. A second-generation microRNA-based assay for diagnosing tumor tissue origin. The oncologist 2012;17(6):801-812. Go to original source...
  19. Jing D, Hao J, Shen Y, Tang G, Li ML, Huang SH et al. The role of microRNAs in bone remodeling. International journal of oral science 2015;7(3):131-143. Go to original source...
  20. Nugent M. MicroRNAs and Fracture Healing. Calcified tissue interna­ tional 2017;101(4):355-361. Go to original source...
  21. Liu T, Qin AP, Liao B, Shao HG, Guo LJ, Xie GQ et al. A novel microRNA regulates osteoclast differentiation via targeting protein in­ hibitor of activated STAT3 (PIAS3). Bone 2014;67:156-165. Go to original source...
  22. Sugatani T, Hildreth BE 3rd, Toribio RE, Malluche HH, Hruska KA Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity. Journal of cellu­ lar biochemistry 2014;115(6):1043-1047. Go to original source...
  23. Kumar S, Vijayan M, Bhatti JS, Reddy PH. MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases. Progress in molecular biology and translational science 2017;146:47-94. Go to original source...




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