Clin Osteol 2007; 12(2): 62-67

Vitamin D - new findings and endocrine microsystemsOriginal contributions

B. Kalvachová

For a long time, vitamin D contained in cod liver oil has been used to prevent rickets in infants. Yet only after the chemical structure of provitamins D and their transfer to effective metabolites were discovered in the 1960s, the complex impact of this vitamin on the human organism has been gradually understood. Some of these findings have already been utilized in practice, others are used in cli­ nical studies. Information on calcitriol, its local formation, binding to nuclear receptors and local effect in tissues has resulted in un­ derstanding vitamin D endocrine microsystems. These findings, together with a sophisticated revision of the recommended daily in­ take of vitamin D in adults, provide potential prevention of many diseases in a natural way that does not increase treatment costs.

Keywords: provitamins D, calcitriol endocrine microsystems, saturationfactors, daily need ofcholecalciferol

Published: December 11, 2007  Show citation

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Kalvachová B. Vitamin D - new findings and endocrine microsystems. Osteologický bulletin. 2007;12(2):62-67.
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    References

    1. Vieth R. Vitamin D Nutrition and Its Potential Health Benefits for Bone, and Other Conditions. Journal of Nutritional Environmental Medicine 2001;11: 275-291. Go to original source...
    2. Spustová V, Dzúrik R. Vitamín D: syntéza, metabolizmus, regulácie a h deficitu u pacientov s chronických ochorením obličiek. Vnitř Lék 2004;7: 537-543.
    3. Blahoš J. Význam vitaminu D. Lékařské listy 20;2006:25-26.
    4. Blahoš J. Kalcitropní hormony a kalciofosfátový metabolizmus. In: Kreze A, Lan­ ger P, Klimeš I, Stárka L, J^yer J, Michálek J. eds: Všeobecná a klinická endo nológia. Bratislava, AEP 2004:316-317.
    5. Keen RW, Egger P, Fall C, Major PJ, Lanchbury JS, Spector TD, Cooper C. Po­ lymorphisms of the Vitamin D Receptor, Infant Growth and Adult Bone Mass. Calcif Tissue Int 1997;60:233-35. Go to original source...
    6. Diamond T, Smerdely P, Kormas N. et al. Hip fracture in elderly men: the imp tance of subclinical vitamin D deficiency and hypogonadism. Med J Aust 1998; 169:138-141. Go to original source...
    7. Glerup H, Mikkelsen K, Poulsen L et al. Hypovitaminosis D myopathy without osteomalacic bone involvement. Calcif Tissue Int 2000;66:419-424. Go to original source...
    8. Sulková S, Fořtová M, Uhrová J, Zima T. Význam stanovení metabolitů vitaminu D u pacientů se sníženou funkcí ledvin. Vnitř Lék 2004;7:510-518.
    9. Chonchol M, Scragg R. 25-Hydroxyvitamin D, insulin resistance and kidney fu tion in the Third National Health and Nutrition Examination Survey. Kidney Int 2007;71(2):134-139. Go to original source...
    10. Hayes CE, Nashold FE, Spach KM, Pedersen LB. The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand) 2003;49(2): 277-300.
    11. Posonby AL, McMichael A, van der Mei I. Ultraviolet radiation and auto disease: insights from epidemiological research. Toxicology 2002;27:71-78. Go to original source...
    12. Zittermann A Vitamin D and disease prevention with special reference to vascular disease. Prog Biophys Mol Biol 2006;92(1):39-48.
    13. Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S, Kimmig R, Mann K, Janssen OE. Low serum 25-hydroxyvitamin D concentrations are asso­ ciated with insulin resistance and obesity in women wi me. Exp Clin Endocrinol Diabetes 2006;114(10):577-583. Go to original source...
    14. Borissova AM, Tankova T, Kirilov G. The effect of vitamin D3 on insulin secre­ tion and peripheral 2003;57(4):258-261.
    15. McGrath J. Does "imprinting" with low prenatal vitamin D contribute to th of various adult disorders? Medical Hypotheses 2001;56:367-371. Go to original source...
    16. Li YCh, Qiao G, Uskokovic M, Xiang W, Zheng W, Kong J. Vitamin D: a nega­ tive endocrine regulator of the renin-angiotensi nal of Cellular Biochemistry 2004;89-90:387-392. Go to original source...
    17. Zittermann A, Schleithoff SS, Tenderich G, Berthold HK, Korfer R, Stehle P. vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol 2003;41:105-112. Go to original source...
    18. Zittermann A, Schleithoff SS, Koerfer R. Vitamin D insufficiency in conge heart failure: why and what to do about it ? Heart Fail Rev 2006;11(1):25-33. Go to original source...
    19. Woo TC, Choo R, Jamieson M. Potential Role of Vitamin D (cholecalciferol) in Patients with PSA Relapse after Definitive Therapy. Nutr Cancer 2005; 51(1):32-36. Go to original source...
    20. Norman PE, Powell JT. Vitamin D, Shedding Light on the Development se in Peripheral Arteries. Arterioscler Thromb Vasc Biol 2005;25:39-46. Go to original source...
    21. Welsh JE, Wietzke JA, Zinser GM et al. Vitamin D3 Breast Cancer prevention. J Nutr 2003;133:24255-24335. Go to original source...
    22. Waterland RA, Garza C. Potential mechanisms of metabolic imprinting tha to chronic disease. American Journal of Clinical Nutrition 1999;69:179-197. Go to original source...
    23. Grant WB. An estimate of excess cancer mortality in the US due to inadequat posure to solar UV-B radiation. Photodermatol Photoimmunol Photomed 2001;17:142.
    24. Calvo MS, Whiting SJ. Overview of the Proceedings from Experimental Biology 2004 Symposium: Vitamin D Insufficiency: A Significant Risk Factor in Chronic Diseases and Potential Disease-Specific Biomarkers of Vitamin D Sufficiency. J Nutr 2005;135:301-303. Go to original source...
    25. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D suf ciency: implications for establishing a new effective dietary intake recommenda­ tion for vitamin D. J Nutr 2005;135:317-322. Go to original source...
    26. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier JP, Vieth R. Estima­ tes of optimal vitamin D status. Osteoporos Int 2005;16:713-716. Go to original source...
    27. Heaney RP. The Vitamin D requirement in health and disease. J Steroid Biochem Mol Biol 2005;97(1-2):13-19. Go to original source...

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