Clin Osteol 2009; 14(1): 22-28

McCune-Albright syndrome - 11 years of experience with bisphosphonate treatmentReview articles

J. Kollerová

A case report of an adult female patient with McCune-Albright syndrome is presented. The clinical picture is dominated by bone in­ volvement, hyperthyroidism and persistent hyperoestrogenism. There is no widely accepted consensus in the treatment of these con­ ditions. Although administration of bisphosphonates is beneficial, no available treatment can completely stop the progression of bone disease. Treatment of hyperoestrogenism is still a matter of debate and is reserved for patients who wish to conceive. The clinical si­ gnificance of other organ system involvement such as sinus tachycardia, long QTc or liver disease is not yet clear. The case report des­ cribes our experience with 11 years of bisphosphonate treatment.

Keywords: McCune-Albright syndrome, polyostoticfibrous dysplasia, peripheral hyperoestrogenism, G protein

Published: June 11, 2009  Show citation

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Kollerová J. McCune-Albright syndrome - 11 years of experience with bisphosphonate treatment. Osteologický bulletin. 2009;14(1):22-28.
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